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Simulation Modeling of coronary ARTery disease: a tool for clinical decision support

Objective

SMARTool aims at developing a platform based on cloud technology, for the management of patients with coronary artery disease (CAD) by standardizing and integrating heterogeneous health data, including those from key enabling technologies. The platform includes existing multiscale and multilevel ARTreat (FP7-224297) models of coronary plaque progression based on non-invasive coronary CT angiography (CCTA) and fractional flow reserve computation, refined by heterogeneous patient-specific non-imaging data (history, lifestyle, exposome, biohumoral data, genotyping) and cellular/molecular markers derivable from a microfluidic device for on-chip blood analysis. SMARTool models will be applied and validated by historical and newly acquired CCTA imaging plus non-imaging health data from the EVINCI project (FP7-222915) population.
SMARTool cloud-based platform, through Human Computer Interaction techniques, 3D visual representation and artery models, will use heterogeneous data in a standardized format as input, providing as output a CDSS - assisted by a microfluidic device as a point of care testing of inflammatory markers – for:
i) Patient specific CAD stratification - existing models, based on clinical risk factors, will be implemented by patient genotyping and phenotyping to stratify patients with non-obstructive CAD, obstructive CAD and those without CAD, ii) site specific plaque progression prediction - existing multiscale and multilevel ARTreat tools of CAD progression prediction will be refined by genotyping and phenotyping parameters and tested by baseline and follow CCTA and integrated by non-imaging patient-specific data, iii) patient-specific CAD diagnosis and treatment - life style changes, standard or high intensity medical therapy and a virtual angioplasty tool to provide the optimal stent type(s) and site(s) for appropriate deployment.

Call for proposal

H2020-PHC-2015-single-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 1 200 411,25

Participants (10)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 220 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
FAKULTET INZENJERSKIH NAUKA UNIVERZITETA U KRAGUJEVCU
Serbia
EU contribution
€ 319 500
Address
Sestre Janjic 6
34000 Kragujevac
Activity type
Higher or Secondary Education Establishments
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 675 000
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
ALACRIS THERANOSTICS GMBH
Germany
EU contribution
€ 811 375
Address
Max Planck Strasse 3
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TURUN YLIOPISTO
Finland
EU contribution
€ 208 073,75
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
EXPRIVIA SPA
Italy
EU contribution
€ 318 952,50
Address
Via Adriano Olivetti 11
70056 Molfetta
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 0
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA
Italy
EU contribution
€ 343 476,25
Address
Via Trieste 41
56126 Pisa
Activity type
Research Organisations
MICRONIT HOLDING BV
Netherlands
EU contribution
€ 372 695
Address
Colosseum 15
7521 PV Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOTRONICS 3D LIMITED
United Kingdom
EU contribution
€ 331 375
Address
5 Greenwich View Place City Reach Third Floor Suite D
E14 9NN London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)