Objective SMARTool aims at developing a platform based on cloud technology, for the management of patients with coronary artery disease (CAD) by standardizing and integrating heterogeneous health data, including those from key enabling technologies. The platform includes existing multiscale and multilevel ARTreat (FP7-224297) models of coronary plaque progression based on non-invasive coronary CT angiography (CCTA) and fractional flow reserve computation, refined by heterogeneous patient-specific non-imaging data (history, lifestyle, exposome, biohumoral data, genotyping) and cellular/molecular markers derivable from a microfluidic device for on-chip blood analysis. SMARTool models will be applied and validated by historical and newly acquired CCTA imaging plus non-imaging health data from the EVINCI project (FP7-222915) population. SMARTool cloud-based platform, through Human Computer Interaction techniques, 3D visual representation and artery models, will use heterogeneous data in a standardized format as input, providing as output a CDSS - assisted by a microfluidic device as a point of care testing of inflammatory markers – for: i) Patient specific CAD stratification - existing models, based on clinical risk factors, will be implemented by patient genotyping and phenotyping to stratify patients with non-obstructive CAD, obstructive CAD and those without CAD, ii) site specific plaque progression prediction - existing multiscale and multilevel ARTreat tools of CAD progression prediction will be refined by genotyping and phenotyping parameters and tested by baseline and follow CCTA and integrated by non-imaging patient-specific data, iii) patient-specific CAD diagnosis and treatment - life style changes, standard or high intensity medical therapy and a virtual angioplasty tool to provide the optimal stent type(s) and site(s) for appropriate deployment. Fields of science medical and health scienceshealth scienceshealth care serviceseHealthengineering and technologymedical engineeringdiagnostic imagingcomputed tomographymedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health scienceshealth sciencespersonalized medicineengineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysis Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.5. - Methods and data Topic(s) PHC-30-2015 - Digital representation of health data to improve disease diagnosis and treatment Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2015-single-stage Funding Scheme RIA - Research and Innovation action Coordinator CONSIGLIO NAZIONALE DELLE RICERCHE Net EU contribution € 1 200 411,25 Address PIAZZALE ALDO MORO 7 00185 Roma Italy See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 200 411,25 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ACADEMISCH ZIEKENHUIS LEIDEN Netherlands Net EU contribution € 220 000,00 Address ALBINUSDREEF 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 220 000,00 FAKULTET INZENJERSKIH NAUKA UNIVERZITETA U KRAGUJEVCU Serbia Net EU contribution € 319 500,00 Address SESTRE JANJIC 6 34000 Kragujevac See on map Region Србија - југ Регион Шумадије и Западне Србије Шумадијска област Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 319 500,00 IDRYMA TECHNOLOGIAS KAI EREVNAS Greece Net EU contribution € 675 000,00 Address N PLASTIRA STR 100 70013 Irakleio See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 675 000,00 ALACRIS THERANOSTICS GMBH Germany Net EU contribution € 811 375,00 Address MAX PLANCK STRASSE 3 12489 Berlin See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 811 375,00 TURUN YLIOPISTO Finland Net EU contribution € 110 422,50 Address YLIOPISTONMAKI 20014 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 208 073,75 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA Finland Net EU contribution € 97 651,25 Address KIINAMYLLYNKATU 4-8 20520 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 97 651,25 EXPRIVIA SPA Italy Net EU contribution € 318 952,50 Address VIA ADRIANO OLIVETTI 11 70056 Molfetta See on map Region Sud Puglia Bari Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 318 952,50 UNIVERSITAT ZURICH Switzerland Net EU contribution € 0,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 207 000,00 FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA Italy Net EU contribution € 343 476,25 Address VIA TRIESTE 41 56126 Pisa See on map Region Centro (IT) Toscana Pisa Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 343 476,25 MICRONIT HOLDING BV Netherlands Net EU contribution € 372 695,00 Address COLOSSEUM 15 7521 PV Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 372 695,00 BIOTRONICS 3D LIMITED United Kingdom Net EU contribution € 331 375,00 Address 10 UPPER BERKELEY STREET W1H 7PE LONDON See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region London Inner London — West Westminster Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 331 375,00
