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Simulation Modeling of coronary ARTery disease: a tool for clinical decision support

Simulation Modeling of coronary ARTery disease: a tool for clinical decision support

Objective

SMARTool aims at developing a platform based on cloud technology, for the management of patients with coronary artery disease (CAD) by standardizing and integrating heterogeneous health data, including those from key enabling technologies. The platform includes existing multiscale and multilevel ARTreat (FP7-224297) models of coronary plaque progression based on non-invasive coronary CT angiography (CCTA) and fractional flow reserve computation, refined by heterogeneous patient-specific non-imaging data (history, lifestyle, exposome, biohumoral data, genotyping) and cellular/molecular markers derivable from a microfluidic device for on-chip blood analysis. SMARTool models will be applied and validated by historical and newly acquired CCTA imaging plus non-imaging health data from the EVINCI project (FP7-222915) population.
SMARTool cloud-based platform, through Human Computer Interaction techniques, 3D visual representation and artery models, will use heterogeneous data in a standardized format as input, providing as output a CDSS - assisted by a microfluidic device as a point of care testing of inflammatory markers – for:
i) Patient specific CAD stratification - existing models, based on clinical risk factors, will be implemented by patient genotyping and phenotyping to stratify patients with non-obstructive CAD, obstructive CAD and those without CAD, ii) site specific plaque progression prediction - existing multiscale and multilevel ARTreat tools of CAD progression prediction will be refined by genotyping and phenotyping parameters and tested by baseline and follow CCTA and integrated by non-imaging patient-specific data, iii) patient-specific CAD diagnosis and treatment - life style changes, standard or high intensity medical therapy and a virtual angioplasty tool to provide the optimal stent type(s) and site(s) for appropriate deployment.
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 200 411,25

Participants (11)

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ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 220 000

FAKULTET INZENJERSKIH NAUKA UNIVERZITETA U KRAGUJEVCU

Serbia

EU Contribution

€ 319 500

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Greece

EU Contribution

€ 675 000

ALACRIS THERANOSTICS GMBH

Germany

EU Contribution

€ 811 375

TURUN YLIOPISTO

Finland

EU Contribution

€ 208 073,75

EXPRIVIA SPA

Italy

EU Contribution

€ 318 952,50

EXPRIVIA HEALTHCARE IT SRL

Italy

UNIVERSITAT ZURICH

Switzerland

FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA

Italy

EU Contribution

€ 343 476,25

MICRONIT MICROTECHNOLOGIES BV

Netherlands

EU Contribution

€ 372 695

BIOTRONICS 3D LIMITED

United Kingdom

EU Contribution

€ 331 375

Project information

Grant agreement ID: 689068

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    30 June 2019

Funded under:

H2020-EU.3.1.5.

  • Overall budget:

    € 5 007 858,75

  • EU contribution

    € 4 800 858,75

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy