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Simulation Modeling of coronary ARTery disease: a tool for clinical decision support

Simulation Modeling of coronary ARTery disease: a tool for clinical decision support

Obiettivo

SMARTool aims at developing a platform based on cloud technology, for the management of patients with coronary artery disease (CAD) by standardizing and integrating heterogeneous health data, including those from key enabling technologies. The platform includes existing multiscale and multilevel ARTreat (FP7-224297) models of coronary plaque progression based on non-invasive coronary CT angiography (CCTA) and fractional flow reserve computation, refined by heterogeneous patient-specific non-imaging data (history, lifestyle, exposome, biohumoral data, genotyping) and cellular/molecular markers derivable from a microfluidic device for on-chip blood analysis. SMARTool models will be applied and validated by historical and newly acquired CCTA imaging plus non-imaging health data from the EVINCI project (FP7-222915) population.
SMARTool cloud-based platform, through Human Computer Interaction techniques, 3D visual representation and artery models, will use heterogeneous data in a standardized format as input, providing as output a CDSS - assisted by a microfluidic device as a point of care testing of inflammatory markers – for:
i) Patient specific CAD stratification - existing models, based on clinical risk factors, will be implemented by patient genotyping and phenotyping to stratify patients with non-obstructive CAD, obstructive CAD and those without CAD, ii) site specific plaque progression prediction - existing multiscale and multilevel ARTreat tools of CAD progression prediction will be refined by genotyping and phenotyping parameters and tested by baseline and follow CCTA and integrated by non-imaging patient-specific data, iii) patient-specific CAD diagnosis and treatment - life style changes, standard or high intensity medical therapy and a virtual angioplasty tool to provide the optimal stent type(s) and site(s) for appropriate deployment.

Coordinatore

CONSIGLIO NAZIONALE DELLE RICERCHE

Indirizzo

Piazzale Aldo Moro 7
00185 Roma

Italia

Tipo di attività

Higher or Secondary Education Establishments

Contributo UE

€ 1 200 411,25

Partecipanti (11)

Classifica in ordine alfabetico

Classifica per Contributo UE

Espandi tutto

ACADEMISCH ZIEKENHUIS LEIDEN

Paesi Bassi

Contributo UE

€ 220 000

FAKULTET INZENJERSKIH NAUKA UNIVERZITETA U KRAGUJEVCU

Serbia

Contributo UE

€ 319 500

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Grecia

Contributo UE

€ 675 000

ALACRIS THERANOSTICS GMBH

Germania

Contributo UE

€ 811 375

TURUN YLIOPISTO

Finlandia

Contributo UE

€ 208 073,75

EXPRIVIA SPA

Italia

Contributo UE

€ 318 952,50

EXPRIVIA HEALTHCARE IT SRL

Italia

UNIVERSITAT ZURICH

Svizzera

FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA

Italia

Contributo UE

€ 343 476,25

MICRONIT MICROTECHNOLOGIES BV

Paesi Bassi

Contributo UE

€ 372 695

BIOTRONICS 3D LIMITED

Regno Unito

Contributo UE

€ 331 375

Informazioni relative al progetto

ID dell’accordo di sovvenzione: 689068

Stato

Progetto in corso

  • Data di avvio

    1 Gennaio 2016

  • Data di completamento

    30 Giugno 2019

Finanziato da:

H2020-EU.3.1.5.

  • Bilancio complessivo:

    € 5 007 858,75

  • Contributo UE

    € 4 800 858,75

Coordinato da:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italia