Advanced MR methods for characterization of microstructural brain damage

Objective

NMR (Nuclear Magnetic Resonance)-based approaches have affirmed as extremely valuable for applications in neurosciences. Nonetheless, the exquisite flexibility of tissue contrast in magnetic resonance imaging (MRI) that can be obtained by proper manipulation of nuclear spins still offers room for technological improvements which can be quickly expanded to clinical routine. In particular, there is extreme need of imaging methods that allow a correct assessment of microstructural damage in many brain diseases, including – but not limited to – neurodegenerative diseases. Indeed, current MRI techniques suffer from poor specificity and ultimately lack the ability to identify the microscopic biophysical and biological mechanisms related to the specific features of the pathology.
This project aims at expanding the set of MR based techniques available to neuroscientists to characterize microstructural damage, assessing the usefulness of these approaches in some specific pathologies where they offer more promise. Notably, this project aims also at establishing the increased specificity and sensitivity of newly developed and current techniques when merged in a truly multiparametric analysis approach.
This project is heavily based on networking activities for exchanging the complimentary knowledge available at the different world-class academic and commercial EU and third country sites. The novel MRI pulse sequences and data analyses approaches tested and validated during the course of the project will be available at each site of the consortium, and will be made available to the scientific community as well.

Field of science

• /medical and health sciences/basic medicine/pathology
• /natural sciences/computer and information sciences/data science/data analysis
• /medical and health sciences/basic medicine/neurology/parkinson
• /medical and health sciences/health sciences/public and environmental health
• /engineering and technology/medical engineering/diagnostic imaging/magnetic resonance imaging
• /medical and health sciences/basic medicine/neurology/multiple sclerosis
• /natural sciences/biological sciences/neurobiology

Programme(s)

• H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge

Topic(s)

• MSCA-RISE-2015 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Call for proposal

H2020-MSCA-RISE-2015
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

MUSEO STORICO DELLA FISICA E CENTRO STUDI E RICERCHE ENRICO FERMI

Address

Via Panisperna 89/A
00184 Roma
Italy

Activity type

Research Organisations

EU contribution

€ 162 000

Participants (5)

ITA-SUOMEN YLIOPISTO

Finland

EU contribution

€ 90 000

Address

Yliopistonranta 1 E
70211 Kuopio

Activity type

Higher or Secondary Education Establishments

Masarykova univerzita

Czechia

EU contribution

€ 90 000

Address

Zerotinovo Namesti 9
60177 Brno Stred

Activity type

Higher or Secondary Education Establishments

CHARLES RIVER DISCOVERY RESEARCH SERVICES FINLAND OY

Finland

EU contribution

€ 54 000

Address

Microkatu 1
70210 Kuopio

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

FAKULTNI NEMOCNICE U SV. ANNY V BRNE

Czechia

EU contribution

€ 90 000

Address

Pekarska 53
656 91 Brno

Activity type

Higher or Secondary Education Establishments

UNIVERSITA DEGLI STUDI DI SALERNO

Italy

EU contribution

€ 54 000

Address

Via Giovanni Paolo Ii 132
84084 Fisciano Sa

Activity type

Higher or Secondary Education Establishments

Partners (1)

REGENTS OF UNIVERSITY OF MINNESOTA

United States

Address

Oak Street Se 200 Mcnamara Alumni Center 450
55455 2070 Minneapolis Mn

Activity type

Higher or Secondary Education Establishments