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High level Integrated SEnsor for NanoToxicity Screening

Objective

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /engineering and technology/nanotechnology/nano-materials

Call for proposal

H2020-NMP-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 411 205

Participants (10)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 899 990
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 631 875
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Blueprint Product Design Ltd
United Kingdom
EU contribution
€ 500 050
Address
38 Market Street
BD21 5AD Keighley
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE
Slovakia
EU contribution
€ 508 745
Address
Vazovova 5
81243 Bratislava
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 368 750
Address
Karlsplatz 13
1040 Wien
Activity type
Higher or Secondary Education Establishments
BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED

Participation ended

Slovakia
EU contribution
€ 0
Address
Dubravska Cesta 9
845 05 Bratislava
Activity type
Research Organisations
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
EU contribution
€ 341 250
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Activity type
Research Organisations
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 270 000
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 800 960
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
NORSK INSTITUTT FOR LUFTFORSKNING STIFTELSE
Norway
EU contribution
€ 300 000
Address
Instituttveien 18
2027 Kjeller
Activity type
Research Organisations