Objective
A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other
computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencescomputer and information sciencesdatabases
- natural sciencesphysical sciencesatomic physics
- natural sciencescomputer and information sciencescomputational science
- engineering and technologynanotechnologynano-materials
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
4 Dublin
Ireland
See on map
Participants (12)
10691 Stockholm
See on map
85764 Neuherberg
See on map
2100 Kobenhavn
See on map
75014 Paris Cedex 14
See on map
1000 Ljubljana
See on map
SW7 2AZ London
See on map
54052 Nancy Cedex
See on map
Participation ended
CB4 0WN Cambridge
See on map
00250 Helsinki
See on map
79183 Waldkirch
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
0363 Oslo
See on map
CV4 7HP Coventry
See on map