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Smart Tools for Gauging Nano Hazards

Objective

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other
computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

Call for proposal

H2020-NMP-2014-2015

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Sub call

H2020-NMP-2015-two-stage

Coordinator

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Net EU contribution
€ 1 695 517,50
Address
Belfield
4 Dublin
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (12)

STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 666 625,00
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 1 058 870,00
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO
Denmark
Net EU contribution
€ 799 820,00
Address
Lerso Parkalle 105
2100 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE
France
Net EU contribution
€ 799 327,50
Non-EU contribution
€ 0,00
INSTITUT JOZEF STEFAN
Slovenia
Net EU contribution
€ 825 250,00
Address
Jamova 39
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 857 548,75
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE DE LORRAINE
France
Net EU contribution
€ 710 793,75
Address
Cours Leopold 34
54052 Nancy Cedex

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Region
Grand Est Lorraine Meurthe-et-Moselle
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
DASSAULT SYSTEMES BIOVIA LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 21 590,25
Address
Milton Road Cambridge Science Park Unit 334
CB4 0WN Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
TYOTERVEYSLAITOS
Finland
Net EU contribution
€ 203 273,75
Address
Topeliuksenkatu 41 B
00250 Helsinki

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
VITROCELL SYSTEMS GMBH
Germany
Net EU contribution
€ 320 348,00
Address
Fabrik Sonntag 3
79183 Waldkirch

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Baden-Württemberg Freiburg Emmendingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,63
STATENS ARBEIDSMILJOINSTITUTT
Norway
Net EU contribution
€ 0,00
Address
Gydas Vei 8
0363 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Research Organisations
Non-EU contribution
€ 151 180,00
DASSAULT SYSTEMES UK LTD
United Kingdom
Net EU contribution
€ 37 159,75
Address
Milburn Hill Road Riley Court Suite 9
CV4 7HP Coventry

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Region
West Midlands (England) West Midlands Coventry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00