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Smart Tools for Gauging Nano Hazards

Objectif

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other
computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

Appel à propositions

H2020-NMP-2014-2015

Voir d’autres projets de cet appel

Sous appel

H2020-NMP-2015-two-stage

Coordinateur

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Contribution nette de l'UE
€ 1 695 517,50
Adresse
Belfield
4 Dublin
Irlande
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00

Participants (12)

STOCKHOLMS UNIVERSITET
Suède
Contribution nette de l'UE
€ 666 625,00
Adresse
Universitetsvagen 10
10691 Stockholm
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Allemagne
Contribution nette de l'UE
€ 1 058 870,00
Adresse
Ingolstadter Landstrasse 1
85764 Neuherberg
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO
Danemark
Contribution nette de l'UE
€ 799 820,00
Adresse
Lerso Parkalle 105
2100 Kobenhavn
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE
France
Contribution nette de l'UE
€ 799 327,50
Adresse
Rue Olivier Noyer 30
75014 Paris Cedex 14
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
INSTITUT JOZEF STEFAN
Slovénie
Contribution nette de l'UE
€ 825 250,00
Adresse
Jamova 39
1000 Ljubljana
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Contribution nette de l'UE
€ 857 548,75
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
UNIVERSITE DE LORRAINE
France
Contribution nette de l'UE
€ 710 793,75
Adresse
Cours Leopold 34
54052 Nancy Cedex
Type d’activité
Higher or Secondary Education Establishments
Contribution hors UE
€ 0,00
DASSAULT SYSTEMES BIOVIA LIMITED

Participation terminée

United Kingdom
Contribution nette de l'UE
€ 21 590,25
Adresse
Milton Road Cambridge Science Park Unit 334
CB4 0WN Cambridge
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00
TYOTERVEYSLAITOS
Finlande
Contribution nette de l'UE
€ 203 273,75
Adresse
Topeliuksenkatu 41 B
00250 Helsinki
Type d’activité
Research Organisations
Contribution hors UE
€ 0,00
VITROCELL SYSTEMS GMBH
Allemagne
Contribution nette de l'UE
€ 320 348,00
PME

L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.

Oui
Adresse
Fabrik Sonntag 3
79183 Waldkirch
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,63
Région
Baden-Württemberg Freiburg Emmendingen
 
STATENS ARBEIDSMILJOINSTITUTT
Norvège
Contribution nette de l'UE
€ 0,00
Adresse
Gydas Vei 8
0363 Oslo
Type d’activité
Research Organisations
Contribution hors UE
€ 151 180,00
DASSAULT SYSTEMES UK LTD
United Kingdom
Contribution nette de l'UE
€ 37 159,75
Adresse
Milburn Hill Road Riley Court Suite 9
CV4 7HP Coventry
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contribution hors UE
€ 0,00
Région
West Midlands (England) West Midlands Coventry