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Smart Tools for Gauging Nano Hazards

Informations projet

N° de convention de subvention: 686098

État

Projet en cours

  • Date de début

    1 Mars 2016

  • Date de fin

    29 Février 2020

Financé au titre de:

H2020-EU.2.1.2.2.

  • Budget total:

    € 7 996 124,88

  • Contribution de l’UE

    € 7 996 124,25

Coordonné par:

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Irlande

Objectif

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other
computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

Coordinateur

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Adresse

Belfield
4 Dublin

Irlande

Type d’activité

Higher or Secondary Education Establishments

Contribution de l’UE

€ 1 695 517,50

Participants (10)

STOCKHOLMS UNIVERSITET

Suède

Contribution de l’UE

€ 666 625

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Allemagne

Contribution de l’UE

€ 1 058 870

DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO

Danemark

Contribution de l’UE

€ 799 820

INSTITUT NATIONAL DE RECHERCHE ET DE SECURITE POUR LA PREVENTION DES ACCIDENTS DU TRAVAIL ET DES MALADIES PROFESSIONNELLES ASSOCIATION

France

Contribution de l’UE

€ 799 327,50

INSTITUT JOZEF STEFAN

Slovénie

Contribution de l’UE

€ 825 250

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Royaume-Uni

Contribution de l’UE

€ 857 548,75

UNIVERSITE DE LORRAINE

France

Contribution de l’UE

€ 710 793,75

DASSAULT SYSTEMES BIOVIA LIMITED

Royaume-Uni

Contribution de l’UE

€ 58 750

TYOTERVEYSLAITOS

Finlande

Contribution de l’UE

€ 203 273,75

VITROCELL SYSTEMS GMBH

Allemagne

Contribution de l’UE

€ 320 348

Informations projet

N° de convention de subvention: 686098

État

Projet en cours

  • Date de début

    1 Mars 2016

  • Date de fin

    29 Février 2020

Financé au titre de:

H2020-EU.2.1.2.2.

  • Budget total:

    € 7 996 124,88

  • Contribution de l’UE

    € 7 996 124,25

Coordonné par:

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Irlande