CORDIS
EU research results

CORDIS

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Molecular Mechanisms of Endometriosis

Project information

Grant agreement ID: 691058

Status

Closed project

  • Start date

    1 January 2016

  • End date

    31 December 2019

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 346 500

  • EU contribution

    € 346 500

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

Objective

Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.
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Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Address

Schlossplatz 2
48149 Muenster

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 63 000

Participants (6)

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 40 500

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 81 000

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 54 000

SEREND-IP GMBH

Germany

EU Contribution

€ 13 500

AQUILA BIOMEDICAL LIMITED

United Kingdom

TERVISETEHNOLOOGIATE ARENDUSKESKUS AS

Estonia

EU Contribution

€ 94 500

Partners (2)

CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)

Argentina

UNIVERSIDAD DE CHILE

Chile

Project information

Grant agreement ID: 691058

Status

Closed project

  • Start date

    1 January 2016

  • End date

    31 December 2019

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 346 500

  • EU contribution

    € 346 500

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany