Objectif Protein aggregation is associated with some of the most prevalent and devastating neurodegenerative disorders in our society, including Alzheimer’s and Parkinson’s diseases. The intricate details of the aggregation process are now beginning to emerge through major efforts for characterizing the associated protein deposits . However, knowledge about the aggregation of membrane proteins, which account for about one third of the human genome , is still almost completely missing despite increasing evidence that implicates in particular the aggregation of those in the respiratory chain and glucose metabolism in pathological pathways.To cover this huge gap, this project is aimed at elucidating the association of membrane protein aggregation with neurodegenerative diseases. The extensive biophysical investigation of the aggregates of two model sugar transporter proteins, galactose (GalP) and lactose (LacY) permeases, is proposed. Initially, controlled ways to promote the aggregation of these two proteins will be investigated in detail. The use of a range of biophysical spectroscopic methods is proposed to obtain information on the nature of the aggregates and their formation process. Further in vivo experiments will probe bacterial ageing in the presence of these aggregates. This work is expected to lead to new insights into the nature of membrane protein aggregates, characterization of their formation, and determination of their possible roles in neurodegenerative processes. Champ scientifique medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingmedical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2015 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contribution nette de l'UE € 183 454,80 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Royaume-Uni Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 183 454,80