We have established a new experimental model, which allows us to investigate how the microbiota regulates human immune function in the lung. The use of our innovative in vivo model makes the results more relevant to humans, given that important differences exist between mice and humans in terms of the immune system, inflammatory responses, and the microbiota. At the beginning of the project, the MSC Fellow/researcher obtained in-depth training in all the experimental techniques required for the project. Specifically, the Fellow learned how to generate and work with the new model developed by the supervisor in order to study human lung immunity in vivo. In addition, the Fellow gained a lot of knowledge about the microbiota field and the latest developments in the area of immunology. During the rest of the 10 month reporting period, significant progress has been made in obtaining the objectives of the proposed work packages. A further improved version of the model was validated and used to demonstrate that important human immune cell types can be study in vivo in our new model. The experiments to examine how the microbiota regulates human immune function have been initiated. Finally, a model to study lung inflammation has been set up.
All research findings obtained so far in this project have been disseminated by presenting them at research seminars and joint meetings with collaborators. The final results of the project will be published in high-impact scientific journals with the MSC Fellow/researcher as a co-author.