CORDIS
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CORDIS

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Driving asymmetric photoreactions by merging organo- and gold-catalysis

Project information

Grant agreement ID: 702405

Status

Closed project

  • Start date

    6 May 2016

  • End date

    5 May 2018

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 158 121,60

  • EU contribution

    € 158 121,60

Coordinated by:

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA

Spain

Objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. Also, the chemistry community has recently recognized how visible light-mediated photoreactions can open new avenues in modern organic synthesis and the past seven years have witnessed its remarkable prosperity. Therefore, developing photo-facilitated asymmetric reactions focusing on rapidly generating privileged chiral natural-like compounds for drug discovery are highly desirable.
The proposed research aims to combine the fellow’s experience in gold catalysis and the host’s experience in photo-triggered organocatalysis (two powerful fields of molecule activation, which have to date remained unrelated) to develop otherwise unachievable catalytic asymmetric photoreactions. Specifically, we will focus on using readily available, unactivated aryl/alkyl chloride or bromide, which cannot be easily activated by the commonly used Rh- or Ir-based photoredox catalysts. The resulting strategies will be used as an ideal platform for assembling libraries comprising enantiopure chiral small molecules bearing α,α-disubstituted α-amino acid & 3,3-disubstituted oxindole frameworks, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S, Copenhagen, DK), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

Coordinator

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA

Address

Avenida Paissos Catalans 16
43007 Tarragona

Spain

Activity type

Research Organisations

EU Contribution

€ 158 121,60

Project information

Grant agreement ID: 702405

Status

Closed project

  • Start date

    6 May 2016

  • End date

    5 May 2018

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 158 121,60

  • EU contribution

    € 158 121,60

Coordinated by:

FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA

Spain