Periodic Reporting for period 1 - GLUTORHIV (Glucose metabolism and mTOR pathway role in CD8+ T cell control of HIV-1)
Reporting period: 2016-04-01 to 2018-03-31
Based on our preliminary data, We made the hypothesis that the extraordinary HIV suppressive capacity of HIV-controllers CD8+ T cells during chronic infection might be associated with an optimal modulation of mTOR pathway (important for differentiation and function) and glucose metabolism (regulates activation, differentiation and functions) fueling those cells.
This work was presented as a poster in national (Sidaction Science Day) and international conferences (Keystone Symposium “Integrating Metabolism and Immunity”, International Pasteur Institute Network Conference) and also led to oral presentations in national conferences (Sidaction Science day, Institut Pasteur Virology Club) and one invited seminar (Pitie salpetriere Hospital).
The presentation of this work during the 2017 International AIDS Society conference was joined by a press release.