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The impact of TFIID on the transcription initiation machinery – a structural perspective.

The impact of TFIID on the transcription initiation machinery – a structural perspective.

Objective

Transcription is a first step of gene expression, a process by which a functional gene product is synthesized based on genetic information from DNA. Gene expression is tightly regulated with complex mechanisms that give cells the flexibility to adapt to a variable environment. Defects in regulation and transcription mechanisms leads to serious pathologies in cells and organisms, that in humans includes cancer development, autoimmunity and neurological disorders, cardiovascular diseases etc.
Structural studies of transcription in the last two decades, brought priceless insight into the mechanisms involved in the process, especially concerning transcription initiation. The next step in understanding gene expression is to combine knowledge about gene regulation with the mechanisms of transcription initiation. I will investigate the molecular basis of gene regulation and transcription initiation interplay using strategy that combine state-of-the-art cryo-electron microscopy, chemical cross-linking, mass-spectrometry and biochemical assays.
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Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Address

Hofgartenstrasse 8
80539 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 159 460,80

Project information

Grant agreement ID: 708500

  • Start date

    1 March 2016

  • End date

    28 February 2018

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 159 460,80

  • EU contribution

    € 159 460,80

Coordinated by:

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany