CORDIS
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Polymer brush sensing arrays for the identification of pathogens

Project information

Grant agreement ID: 702927

Status

Grant agreement terminated

  • Start date

    1 February 2017

  • End date

    31 January 2020

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 258 107,40

  • EU contribution

    € 258 107,40

Coordinated by:

UNIVERSITY OF YORK

United Kingdom

Objective

Surfaces with the capacity for selective recognition of particular pathogens would offer great potential in a number of biomedical applications, including diagnostic devices. Mammalian cells are decorated with a carbohydrate-rich layer, the glycocalyx, which facilitates cellular recognition. Carbohydrate-binding proteins can interact with these sugar motifs to facilitate highly selective recognition, a strategy which is exploited by many viral and bacterial pathogens. Such species have evolved to display recognition units on their surfaces which may interact with considerable affinity with glycan structures displayed on cellular surfaces. This molecular recognition constitutes a key step in the processes of infection or toxicity, and is therefore an attractive target for the development of diagnostic devices. In this project, Dr Clare Mahon proposes to develop surface-tethered polymer brushes which will mimic the glycocalyx in terms of facilitating adhesion of pathogens. Through the incorporation of different fluorophores, the surfaces will be used to construct sensing arrays which will enable the rapid and cost-effective identification of water-borne pathogens and common respiratory pathogens.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITY OF YORK

Address

Heslington
Yo10 5dd York North Yorkshire

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 258 107,40

Partners (1)

THE UNIVERSITY OF SYDNEY

Australia

Project information

Grant agreement ID: 702927

Status

Grant agreement terminated

  • Start date

    1 February 2017

  • End date

    31 January 2020

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 258 107,40

  • EU contribution

    € 258 107,40

Coordinated by:

UNIVERSITY OF YORK

United Kingdom