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Chromatin and Metabolism Chromatin-metabolism interactions as targets for healthy living

Objective

Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chromatin are poorly understood, and drug targets are only starting to be identified. Pioneering experiments by ChroMe labs now reveal how sugars, exercise, the gut microbiome and novel drugs regulate chromatin. These novel links promise to substantially improve our understanding and treatment of metabolic disorders. National governments and the EU invest major resources to address the burden of the “metabolic syndrome”. However, there is an urgent need for expert human capital able to dissect metabolic diseases, exploit new targets and establish innovative therapies. No local nor international program currently provides adequate training at this emerging interface of chromatin and metabolism.

ChroMe establishes a timely and intersectorial ETN that exploits Europe’s strengths in epigenetics, physiology and medicine to translate our molecular knowledge of chromatin–metabolism interactions into therapies. Our ESRs receive advanced training in emerging technologies, bioinformatic and translational approaches, and all engage in collaborative PhD projects co-supervised by academia and industry. ChroMe’s extensive transferable skills, dissemination and public engagement program equips our ESRs with the experience and personal network needed for a career in metabolic health. By systematically involving the non-academic sector at every level in our research, training and management, ChroMe will craft future European leaders with the necessary knowledge and skills to fight the metabolic syndrome pandemic.

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 747 649,44

Participants (11)

FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
Spain
EU contribution
€ 495 745,92
Address
Carrer Muntaner 383 3/2
08021 Barcelona
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 263 659,32
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ROVIRA I VIRGILI
Spain
EU contribution
€ 247 872,96
Address
Carrer De Escorxador
43003 Tarragona
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 262 875,60
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 249 216,48
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 273 287,88
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 249 216,48
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
BIOBAM BIOINFORMATICS SL
Spain
EU contribution
€ 247 872,96
Address
Avenida Peris Y Valero 78-23
46006 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CHRONOS THERAPEUTICS LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
Freize Farm Woodstock Road
OX2 8JX Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
4 SC AG
Germany
EU contribution
€ 249 216,48
Address
Fraunhoferstr. 22
82152 Planegg Martinsried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SOCIETE DES PRODUITS NESTLE SA
Switzerland
EU contribution
€ 265 226,76
Address
Avenue Nestle 55
1800 Vevey
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)