Bio-inspired electrONIC NOSE interfacing olfactory electrical biosensors and carbon NANOtubes

Informazioni relative al progetto

NANOZ-ONIC

ID dell’accordo di sovvenzione: 682286

DOI 10.3030/682286

Progetto concluso

Data della firma CE 15 Aprile 2016

Data di avvio 1 Ottobre 2016

Data di completamento 31 Marzo 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 926 870,00

Contributo UE € 1 926 870,00

Coordinato da

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Obiettivo

The goal of this project is to develop an innovative biosensor for the non-invasive, painless and real-time detection of volatile biomarkers in the exhaled breath of patients. Volatile biomarkers have been identified for several diseases including cancers, diabetes, cystic fibrosis and neurodegeneration. A miniaturized system for fast and simple breath-analysis would not only improve the early detection of these pathologies but also enable point-of-care monitoring of patients either in medical institutions or at home.
Different electronic noses are in development (or even in use for diagnosing asthma), however their generalisation in reliable medical diagnosis devices is mainly hindered by their poor versatility. The main challenge is to quantitatively and simultaneously detect several volatile biomarkers with high specificity and selectivity. The ideal technology would be one which mimicked the natural olfactory systems that recognize odours by combinatorial analysis of receptor responses.
Inspired by this biological example, this project aims at integrating natural olfactory receptors into two state-of-the-art technologies: Ion Channel-Coupled Receptors (ICCRs) and single-walled Carbon NanoTube-Field Effect Transistors (swCNT-FETs). ICCRs are original biosensors created by fusion of G Protein Coupled Receptors (GPCRs) with an ion channel. The recognition of a chemical compound by the GPCR is transduced into an electrical signal by the ion channel. Mammalian olfactory receptors are GPCRs, and the objective of this 5-year project is to engineer an original library of olfactory ICCRs for multiplex detection of volatile biomarkers. To detect the electrical signal with very high sensitivity and at the nanometric scale, ICCRs will be interfaced with swCNT-FET transistors by coating the carbon nanotubes with ICCR-containing nanovesicles. The recent detection of a biomarker with an ICCR-swCNT-FET device by project members demonstrates the feasibility of this approach.

Campo scientifico

• medical and health sciences › clinical medicine › oncology › prostate cancer
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• medical and health sciences › clinical medicine › oncology › lung cancer
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › pathology

Programma(i)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Argomento(i)

• ERC-CoG-2015 - ERC Consolidator Grant

Invito a presentare proposte

ERC-2015-CoG

Meccanismo di finanziamento

ERC-COG - Consolidator Grant

Istituzione ospitante

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

• Contribution nette de l'UE: € 1 434 325,00
• Indirizzo: RUE MICHEL ANGE 3 ; 75794 Paris ; Francia
• Regione: Ile-de-France › Ile-de-France › Paris
• Tipo di attività: Research Organisations
• Costo totale: € 1 434 325,00

Beneficiari (2)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Francia

• Contribution nette de l'UE: € 1 434 325,00
• Indirizzo: RUE MICHEL ANGE 3 ; 75794 Paris
• Regione: Ile-de-France › Ile-de-France › Paris
• Tipo di attività: Research Organisations
• Costo totale: € 1 434 325,00

SEOUL NATIONAL UNIVERSITY

Corea del Sud

• Contribution nette de l'UE: € 492 545,00
• Indirizzo: Sillim-Dong, Gwanak-Gu SAN 56-1 ; 151742 SEOUL
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: € 492 545,00