Objective Food security is a socioeconomical concept that involves access to food that meets people's dietary needs and preferences. Current and future food security is threatened by more frequent and more widespread drought events, leading to reduction in crop yields. A related issue of global importance is micronutrient deficiency. Zinc, a micronutrient involved in all major physiological processes, has outstanding potential to improve crop yields, as well as animal and human health. One long-term and cost-effective approach to overcome zinc deficiency in humans involves biofortification - increasing micronutrients in staple crops.In this context, the molecular processes underlying (a) drought resistance, and (b) micronutrients accumulation in edible parts of crop plants need to be elucidated. One protein family – the plant metallothioneins (MTs) – shows tremendous promise in enhancing drought tolerance, zinc accumulation, and bioavailability.This project aims to analyse the complement of MTs from sorghum, a cereal plant with unusual drought- and heat-resistance that is a staple crop for 500 Million people. Sorghum is predicted to become more prevalent in future European diets.In this project, the questions whether and which MT may be involved in (a) zinc accumulation in grains, (b) discrimination between essential zinc and toxic cadmium, and (c) drought stress tolerance, will be addressed. A unique cross-disciplinary approach spanning in-planta analysis to protein biophysics will furnish unprecedented insight into crucial aspects of plant zinc homeostasis and drought tolerance. Outcomes will impact European scientific excellence by empowering a female scientist from Central Europe, and by inspiring further work in plant science. Future translation of the fundamental insights generated will Iead to applications in agriculture (e.g. novel biofortification strategies for cereals), and enhance the European public’s awareness of the importance of zinc for human health. Fields of science natural scienceschemical sciencesinorganic chemistrybioinorganic chemistrynatural scienceschemical sciencesinorganic chemistrytransition metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingmedical and health scienceshealth sciencesnutritionnatural sciencesbiological sciencesbotany Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2015 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator THE UNIVERSITY OF WARWICK Net EU contribution € 195 454,80 Address Kirby Corner Road - University House CV4 8UW Coventry United Kingdom See on map Region West Midlands (England) West Midlands Coventry Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 195 454,80