Objectif The bacterial cell cycle is of fundamental importance and an important potential antibiotic target; however, many details ofthe molecular mechanisms involved remain elusive. Sporulation in Bacillus subtilis is an important model system for cellcycle studies. Here, I propose applying the ribosome profiling method, not only to identify novel factors involved in the of B.subtilis cell cycle, but also to create a map of factors regulating this process. I will use advanced genetic methods andmicroscopic techniques to characterize the functions of the novel factors, gaining insights into their role in the cell cycle. Myextensive experience in prokaryotic translation gained in the laboratory of Dr. Daniel Wilson in Munich, Germany, combinedwith the exceptional genetics and cell biology expertise of the laboratory of Prof. Jeff Errington in Newcastle, England,creates a great opportunity to study important fundamental aspects of bacteria, with potential implications for healthcare,drug discovery and industrial biotechnology, as well as providing the foundation for a successful independent career inscience. Champ scientifique natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Mots‑clés Cell division cell cycle Bacillus subtilis sprulation ribosome profiling genetics imaging Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2015 Voir d’autres projets de cet appel Régime de financement MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinateur UNIVERSITY OF NEWCASTLE UPON TYNE Contribution nette de l'UE € 183 454,80 Adresse KINGS GATE NE1 7RU Newcastle Upon Tyne Royaume-Uni Voir sur la carte Région North East (England) Northumberland and Tyne and Wear Tyneside Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 183 454,80