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Environmental chemicals as obesogens

Environmental chemicals as obesogens

Objective

Obesity is a serious health risk that has reached epidemic proportions worldwide. Obesity is traditionally considered a as disorder of energy imbalance imposed on a background of genetic disposition. In addition to risk factors such as diet and genetics, chemicals in our environment have emerged as contributing factors associated with an increased risk for obesity (i.e. obesogens). Phthalate esters, a ubiquitous class of chemicals used as plasticizers in products such as toys and hospital supplies, are suspected of being obesogens. Despite studies demonstrating that phthalate urine levels are associated with increased risk to obesity in children, meta-analyses report that current data are insufficient for determining whether phthalates do in fact increase the prevalence of obesity. Moreover, data are sparse on how obesogens affect metabolism and the feeding axis and there are fundamental gaps in our understanding of the precise mechanisms by which environmental chemicals exacerbate this human disease. The central hypothesis of this proposal is that exposures to phthalates will exacerbate molecular responses in the hypothalamus and gut that are observed during a regime of over-feeding. Further, the modification of the gut microbiota may be a relevant consequence of obesogens. The zebrafish (ZF) is one of the most important models in environmental toxicology and developmental biology, and is rapidly becoming a major model for studies in human health and metabolic diseases. ZF will be used to determine mechanisms that are associated to diet and chemical induced obesity, novel regulatory pathways in the hypothalamus and gut will be identified; this is important as these two tissues communicate via the endocrine system and there is direct innervation of the gut by the central nervous system. To be in line with 3R principles, high throughput screen method using ZF embryo will be developed to test environmental chemicals for their “obesogenic” potential.
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Coordinator

Masarykova univerzita

Address

Zerotinovo Namesti 9
60177 Brno Stred

Czechia

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 249 490,80

Partners (1)

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University of Florida

Project information

Grant agreement ID: 707241

Status

Ongoing project

  • Start date

    1 July 2016

  • End date

    30 June 2019

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 249 490,80

  • EU contribution

    € 249 490,80

Coordinated by:

Masarykova univerzita

Czechia