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Identification of insulin signalling factors that delay age-related memory impairment

Obiettivo

Elucidation of the biological mechanisms that govern ageing can facilitate the discovery of evolutionarily conserved factors, which denominate physiological deterioration in humans. Here we will study the effect of insulin/insulin like growth factor signalling (IIS), shown to delay ageing in several organisms, on age-related memory impairment (AMI). We will use both C. elegans and Drosophila as experimental platforms, to test evolutionarily conservation of findings. Longevity combined with memory experiments will be applied in several IIS mutants. We will dissect IIS to find putative mediators of IIS effects on cognitive function. To identify relative mechanisms we will measure activity of known AMI regulators in IIS mutants. Depending on our results, our study will expand on transcription profiling worms and flies IIS mutants of different ages. Neuronal genes differentially affected by IIS will be further studied. We will use novel imaging techniques to characterize morphological changes that occur through ageing in the nervous system. This study is a first step to identify universal mechanisms that underlay cognitive function decline. Pharmacological manipulation of such mechanisms could delay AMI in humans.

Meccanismo di finanziamento

MSCA-IF-EF-ST - Standard EF

Coordinatore

IDRYMA TECHNOLOGIAS KAI EREVNAS
Contribution nette de l'UE
€ 164 653,20
Indirizzo
N PLASTIRA STR 100
70013 Irakleio
Grecia

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Regione
Νησιά Αιγαίου Κρήτη Ηράκλειο
Tipo di attività
Research Organisations
Collegamenti
Costo totale
€ 164 653,20