CORDIS
EU research results

CORDIS

English EN
How Infection History Shapes the Immune System: Pathogen-induced Changes in Regulatory T Cells

How Infection History Shapes the Immune System: Pathogen-induced Changes in Regulatory T Cells

Objective

Studying host-pathogen interactions by focusing on the interaction of a single pathogen with the host has defined our understanding of these events and the insights gained form the basis for the therapeutic and vaccination strategies we use today. However, people become infected with multiple pathogens throughout their lifetime, at times even simultaneously. Still, it is largely unknown how the immune response to one pathogen alters the body’s ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. This project will address this question by focusing on infection-induced changes in regulatory T cells (Tregs) as they may lead to biased suppression and changes in the nature of subsequent immune responses.
Our efforts will focus on two areas: In a first part, we will use single cell RNA-Seq to address how infections shape the Treg compartment by defining the specialized Treg subsets generated during polarized infectious settings and analyzing how they interact with effector T cells. Based on the depth of information we expect to obtain from this approach, we envisage finding thus far unappreciated interactions and functions of Tregs in the course of an immune response. The second part will investigate how an altered Treg compartment, either through genetic modifications or infection-induced, affects disease susceptibility. In this context, we will also address stability and persistence of pathogen-induced changes in the Treg compartment. Collectively the proposed experiments will allow us to start addressing how preceding infections affect disease susceptibility. Deciphering how infection history shapes the Treg compartment and how this affects susceptibility to future challenges will lay the groundwork for addressing this question more broadly in the future and as such will likely have a transformative impact on the field.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

UNIVERSITAT ZURICH

Address

Ramistrasse 71
8006 Zurich

Switzerland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 499 755

Beneficiaries (1)

Sort alphabetically

Sort by EU Contribution

Expand all

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 1 499 755

Project information

Grant agreement ID: 677200

Status

Ongoing project

  • Start date

    1 June 2016

  • End date

    31 May 2021

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 499 755

  • EU contribution

    € 1 499 755

Hosted by:

UNIVERSITAT ZURICH

Switzerland