Objetivo BACKGROUND Ancient DNA research has recently entered the genomics era. Performing“ancient population genomics” is now technically possible. Utilizing the temporal aspect of thisnew data, we can address fundamental evolutionary questions such as the amount of selectionacting on the genome or the mode and tempo of the colonization of the world. AIMS The overall goal of the proposed research is to (i) generate and analyse data to answer two long standing questions in human evolution: understanding the molecular basis of human adaptation to high altitude and investigating the timing of the Polynesian-South American contact, (ii) develop statistical approaches that combine ancient and modern genetic data to estimate the timing and the intensity of a selective sweep and an admixture event. METHODOLOGY Application: We will collect, date and DNA sequence human remains. Combining the ancient genetic data, 14C dates with existing modern genomic data will allow us to increase the resolution as to the timing of the adaptive and the admixture event, respectively, while generating unique datasets. Theory: We will build on existing methods based on one-locus classical population genetic models to develop tools to analyse whole genome time serial data. RELEVANCE Ecological: The results will address the fundamental question of how much of the human genome is undergoing selection, better characterize one of the textbook examples of adaptation in humans and contribute to our understanding of the peopling of the Americas. Medical: We will gain insights into the fundamental stress physiology experienced at high altitude and therefore into altitude-related illnesses. Methodological: The methods developed in this project will not only benefit the growing field of ancient genomics but also other fields where data is collected in a temporal manner, such as experimental evolution and epidemiology Ámbito científico natural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicinephysiologysocial sciencessociologydemographyhuman migrationsnatural sciencesbiological sciencesgeneticsgenomes Palabras clave ancient DNA Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-StG-2015 - ERC Starting Grant Convocatoria de propuestas ERC-2015-STG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-STG - Starting Grant Institución de acogida UNIVERSITE DE LAUSANNE Aportación neta de la UEn € 1 438 018,37 Dirección QUARTIER UNIL CENTRE - BATIMENT UNICENTRE 1015 LAUSANNE Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 438 018,37 Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo UNIVERSITE DE LAUSANNE Suiza Aportación neta de la UEn € 1 438 018,37 Dirección QUARTIER UNIL CENTRE - BATIMENT UNICENTRE 1015 LAUSANNE Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 438 018,37 UNIVERSITAET BERN La participación finalizó Suiza Aportación neta de la UEn € 60 459,63 Dirección HOCHSCHULSTRASSE 6 3012 Bern Ver en el mapa Región Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 60 459,63
