Community Research and Development Information Service - CORDIS

H2020

LUMINOUS

Project ID: 686764
Funded under

Studying, Measuring and Altering Consciousness through information theory in the electrical brain

From 2016-03-01 to 2019-08-31, ongoing project | LUMINOUS Website

Project details

Total cost:

EUR 3 925 588,75

EU contribution:

EUR 3 925 588,50

Coordinated in:

Spain

Call for proposal:

H2020-FETOPEN-2014-2015-RIASee other projects for this call

Funding scheme:

RIA - Research and Innovation action

Objective

Deliverables

  • Ethical Requirements. Issue 1

    Ethical Requirements resulting from 2nd iteration of the Ethical Screening during GA preparation.

  • Experimental plans. Issue 2

    T3.1 Anaesthesia: (UOX, STA, IFADO, UMI): Apply the concepts/protocols employed during sleep stage N1 or dreaming to subjects who are in a state of mild sedation or during the induction of general anaesthesia (MOOAS level 3) in order to probe the capacity of tCS to (1) alter the EEG features of bistability and (2) shift the level of wakefulness. Explore the relationship of the SWAS biomarker within the information theoretic and PCI approach to consciousness state. We will gather ultra high field 7T resting state fMRI paradigms using the developed EEG metrics as end-points for titration of anaesthesia. In particular we will explore the functional thalamocortical connectivity of the sub-regions of thalamus at these EEG end-points, and identify changes in connectivity induced by tCS. Slow activity is a common feature of both sleep and anaesthesia. There is also evidence that some anaesthetics satisfy the homeostatic need for sleep (Pal2011). By using a within-subject design, we will explore the commonality of these mechanisms further by using EEG recordings of sleep prior to fMRI scanning. We will investigate the effect of tCS on the developed EEG consciousness metrics to elucidate whether the proposed brain interference methods will allow the required dose for anaesthesia-induced loss of consciousness to be reduced, thus reducing the known risks of over-anaesthesia.

  • Consciousness: models, metrics and intervention. Issue 1

    T1.1 Neuroscience, Consciousness & Bits (UMI, all): We will review models of consciousness, the relevance of information integration, KAC, bistability, brain rhythms related with consciousness and other explanatory correlates, and study implications for artificial systems and other cognitive sciences. Guide experimental work: specify methods for consciousness characterization, from classical spectral measures to information transfer, connectivity and complex network EEG metrics; explore intrinsic bistability of cortical neurons as a final common pathway leading to a decreased capacity for information integration (indexed by PCI and other metrics) during loss of consciousness; propose how to test hypotheses by studying the effects of different types of perturbations (NIBS, PNS) on EEG recorded during different consciousness conditions; explore the possibility of calculating PCI, or of detecting signs of cortical bistability, starting from stimulation protocols such as tCS and PNS-mediated stimulation (i.e., oddballs, local-global paradigm, subject’s own name); define KAC metrics: 1) using auditory stimuli and study associated functional networks; 2) explore the existence of similar signals using NIBS 3) evaluate tACS perturbation on EEG to create an analogue of sensory ERP. Design techniques to detect the occurrence of perturbation-induced cortical downstates, including period-amplitude analysis of evoked slow waves, time-frequency decomposition and empirical mode decomposition; assess the impact of the downstate on causality at each single recording site by calculating phase-locking factor (Lachaux1999), and the impact of the downstate on causality across recording sites by calculating the phase-locking value (Palva2010). Pre-select appropriate EEG feedback loops in NIBS and guide the EEG feature search (WP2). Finally, organise the 2-3 day yearly project workshops for brainstorming and experimental design. As a final task in the project the experimental results obtained in WP3 will be interpreted and transformed into theoretical advances on consciousness understanding.

  • Experimental results. Issue 1

    T3.2 Sleep (IFADO, UMI, STA): We will explore if lucid dreaming, which is a unique consciousness model in which primary consciousness – normally present during sleep – is transferred to the secondary mode of consciousness, is associated with specific FC alterations beyond regional prefrontal changes as demonstrated recently (Voss2014). We will systematically modulate connectivity to explore if these physiological processes are causally related to lucidity and to which degree specific FC patterns (frequency bands, synchrony) contribute. Oscillatory activity and connectivity will be studied with the advanced EEG models developed in WP1, and interventional stimulation will be performed. We will monitor sleep-dependent alterations of oscillatory activity with specific relation to FC alterations depending on relaxed wakefulness, drowsiness, light sleep, deep slow wave sleep, and REM-sleep in healthy subjects. The results will provide the basis for testing causality via tCS. We will explore consciousness modulation in healthy subjects as well as in patients suffering from sleep disturbance syndromes, i.e., psychophysiological insomnia states, and narcolepsy. The results of this study will elucidate how states of consciousness can be modulated by NIBS, and whether/how pathological alterations of state changes can be counteracted [IFADO]. PCI-based experiments will be conducted on healthy sleeping subjects in order to find the optimal stimulation parameters that are effective in reducing the magnitude and the rate of occurrence of spontaneously occurring and evoked (NIBS, somatosensory, visual, auditory) cortical downstates. It will also allow testing whether tCS, by reducing bistability, may affect the level of consciousness by promoting a sleep stage transition (e.g., from sleep stage N1 to wakefulness, from dreaming to lucid dreaming). [UMI]

  • Experimental plans. Issue 1

    T3.1 Anaesthesia: (UOX, STA, IFADO, UMI): Apply the concepts/protocols employed during sleep stage N1 or dreaming to subjects who are in a state of mild sedation or during the induction of general anaesthesia (MOOAS level 3) in order to probe the capacity of tCS to (1) alter the EEG features of bistability and (2) shift the level of wakefulness. Explore the relationship of the SWAS biomarker within the information theoretic and PCI approach to consciousness state. We will gather ultra high field 7T resting state fMRI paradigms using the developed EEG metrics as end-points for titration of anaesthesia. In particular we will explore the functional thalamocortical connectivity of the sub-regions of thalamus at these EEG end-points, and identify changes in connectivity induced by tCS. Slow activity is a common feature of both sleep and anaesthesia. There is also evidence that some anaesthetics satisfy the homeostatic need for sleep (Pal2011). By using a within-subject design, we will explore the commonality of these mechanisms further by using EEG recordings of sleep prior to fMRI scanning. We will investigate the effect of tCS on the developed EEG consciousness metrics to elucidate whether the proposed brain interference methods will allow the required dose for anaesthesia-induced loss of consciousness to be reduced, thus reducing the known risks of over-anaesthesia.

  • Ethical Advisory Board

    Task D4.1 Ethical Advisory Board

  • Ethical Advisory Board Report. Issue 1

    Report of the external Ethical Advisory Board as requested by the Ethical check

Publications

Coordinator

STARLAB BARCELONA SL
Spain

EU contribution: EUR 612 625


AVENIDA TIBIDABO 47 BIS
08035 BARCELONA
Spain
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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Participants

FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V.
Germany

EU contribution: EUR 567 162,50


ARDEYSTRASSE 67
44139 DORTMUND
Germany
Activity type: Higher or Secondary Education Establishments

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UNIVERSITE DE LIEGE
Belgium

EU contribution: EUR 544 680


PLACE DU 20 AOUT 7
4000 LIEGE
Belgium
Activity type: Higher or Secondary Education Establishments

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UNIVERSITA DEGLI STUDI DI MILANO
Italy

EU contribution: EUR 322 080


Via Festa Del Perdono 7
20122 MILANO
Italy
Activity type: Higher or Secondary Education Establishments

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EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

EU contribution: EUR 475 375


GESCHWISTER-SCHOLL-PLATZ
72074 TUEBINGEN
Germany
Activity type: Higher or Secondary Education Establishments

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

EU contribution: EUR 364 250


RUE DE TOLBIAC 101
75654 PARIS
France
Activity type: Research Organisations

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

EU contribution: EUR 600 776


WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD OXFORD
United Kingdom
Activity type: Higher or Secondary Education Establishments

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HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

EU contribution: EUR 438 640


Ingolstaedter Landstrasse 1
85764 NEUHERBERG
Germany
Activity type: Research Organisations

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