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A paradigm shift in cancer therapy – using mitochondria-powered chemiluminescence to non-invasively treat inaccessible tumours

Objective

Brain cancers such as glioblastoma multiforme (GBM) are practically incurable due to their location, invasiveness and highly aggressive nature. The use of light-based treatments of GBM by activating tumor-localized photosensitizers, such as in photodynamic therapy (PDT) has been clinically evaluated, but with limited success. This is mainly due to the limited penetration of light into tissue and the efficient spread of tumor cells typically up to at least 2 cm from the resection margin. Moreover, the existing photon based treatments (photodynamic therapy) are highly invasive and usually require open-cranium surgery, due to the need for external light sources. In the Lumiblast project the photons are produced inside the tumor cells in the form of chemiluminescence avoiding the major limitation of using external light to treat solid, deep-sited and inaccessible tumors. The principle utilized in Lumiblast may also be relevant for cancers of other origins. Due to its nature Lumiblast is expected to act on individual cells, rather than the collective lesion; it could thus completely eliminate the hitherto incurable GBM. Each GBM cell is expected to become a small lamp providing the light required for the photosensitive agents to become activated, killing the tumour cells from the inside. Lumiblast requires a concerted interdisciplinary action. The project coordinator (Berg’s group, Oslo University Hospital, OUS) is world renowned in PDT and photomedicine, while the team from the University of Athens (Georgios Vougioukalakis’ group, UoA) is up and coming with high expertise in synthetic chemistry. The Polytechnic University of Valencia (Miguel Miranda’s group, UPV) team is headed by a world leader in Photochemistry, the University of Oslo partner (Hanne H. Tønnensen’s group, UiO) is specialized in pharmaceutical formulation, and Knight Scientific Ltd (KSL, CEO Jan Knight) is an SME with an impressive track record in ROS-activated luminescence. This 4.5-year project will establish the Lumiblast breakthrough technology by providing proof-of-concept in extracellular systems, GBM cell cultures and animal models, with the vision to advance Lumiblast to the clinic 5-6 years after the end of the proposed project.

Call for proposal

H2020-FETOPEN-2014-2015-RIA
See other projects for this call

Coordinator

OSLO UNIVERSITETSSYKEHUS HF
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 359 598,75

Participants (4)

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 537 125
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
EU contribution
€ 392 375
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Activity type
Higher or Secondary Education Establishments
KNIGHT SCIENTIFIC LIMITED
United Kingdom
EU contribution
€ 367 500
Address
18 Western College Road
PL4 7AG Plymouth Devon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 374 776,25
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments