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QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy

Objective

The QuIC-ConCePT consortium has 2 objectives:
1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision-making in Phase I trials of investigational therapies, confident that the IBs are technically valid, that a measured change in the IB faithfully reflects the desired change in the underlying tumour pathology, and that the IBs can be readily deployed in multiple cancer centres in a robust, consistent, ethical, and cost-effective way acceptable to patients.
2.(10% of resource, WP6) includes a portfolio of innovative approaches to devise, evaluate and introduce IBs of invasion and metastasis.
The IBs of tumour cell proliferation and necrosis will be developed respectively from FLT PET and ADC MRI respectively. Initial apoptosis plans focus on ICMT11 PET, possibly with other IBs introduced later. The project will be delivered using a portfolio of animal (WP2), human (WP3), image analysis (WP4) and regulatory (WP5) work. The project will be coordinated and the interdependent workpackages integrated in WP1. These WPs will deliver image acquisition and analysis protocols which are technically valid, standardised and suitable for multicentre use. We will evaluate reproducibility, effects of intervention, timing, dose-response, and imaging-histopathology correlation in animals and patients. The project is timely, and highly likely to deliver IBs which will markedly improve drug development, and benefit cancer patients in Europe and globally. The managing entity (EORTC) is already world-leading in the qualification of IBs, and the consortium includes in the academic and EFPIA partners some of the world's most productive and innovative physicians and scientists in cancer imaging.

Call for proposal

IMI-JU-02-2009
See other projects for this call

Coordinator

EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
Address
Avenue E. Mounier 83
1200 Brussels
Activity type
Research Organisations
EU contribution
€ 1 251 050
Principal investigator
Yan Liu (Dr PhD)
Administrative Contact
Stephane Lejeune (Mr)

Participants (23)

ASTRAZENECA AB
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Ms)
Cancer Research UK

Participation ended

EU contribution
€ 88 511
Address
St John Street
EC1V 4AD London
Activity type
Research Organisations
Administrative Contact
Emma Ryley (Dr)
THE UNIVERSITY OF MANCHESTER
EU contribution
€ 545 000
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elizabeth Fay (Ms)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
EU contribution
€ 290 250
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katharina STEINBERG (Dr.)
STICHTING RADBOUD UNIVERSITEIT
EU contribution
€ 225 000
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Kroon (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
EU contribution
€ 340 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Dina FALKENRECK (Mrs)
STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
EU contribution
€ 732 400
Address
Dr. Tanslaan 12
6229 ET Maastricht
Activity type
Research Organisations
Administrative Contact
Floor Franssen (Drs.)
STICHTING VUMC
EU contribution
€ 613 000
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
Administrative Contact
Yvonne Koppelman (Mrs.)
KING'S COLLEGE LONDON
EU contribution
€ 55 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ron Irwin (Mr)
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
EU contribution
€ 445 000
Address
Drie Eikenstraat 655
2650 Edegem
Activity type
Research Organisations
Administrative Contact
Daisy Van Mieghem (Ms)
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
EU contribution
€ 560 800
Address
Old Brompton Road 123
SW7 3RP London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yodry Vasquez (Mr)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
EU contribution
€ 210 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda A. Everse (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
EU contribution
€ 775 000
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carole Meads (Miss)
Keosys S.A.S.
EU contribution
€ 495 000
Address
Impasse Augustin Fresnel
44815 Saint-herblain
Administrative Contact
Anthony MOTTIER (Mr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
EU contribution
€ 125 000
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dario Neri (Professor)
AMGEN
Address
Telecomlaan 5-7
1831 Diegem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rodolphe Eyraud (Mr)
ELI LILLY AND COMPANY LTD
Address
Lilly House Basingview
RG21 4FA Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sally Miles (-)
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Péresse (Mrs.)
PFIZER LIMITED
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr)
F. HOFFMANN-LA ROCHE AG
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jason Hannon (Mr)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Paul Pasquet (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
EU contribution
€ 248 989
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms)