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European Autism Interventions - A Multicentre Study for Developing New Medications

Objective

Despite dramatic advances in molecular and imaging technologies, there are currently no effective pharmacological treatments for the core symptoms of autism spectrum disorder (ASD). Major obstructions to this include a lack of aetiologically-driven or pathophysiologically-accurate animal models; an absence of tests that indicate efficacy; and reliance of clinical trials on DSM/ICD10 categories which provide a collection of biologically heterogeneous patients. Further, even if novel treatments are developed there is no EU platform to clinically test them. Our hypothesis is that a focus on cross-species endophenotypes, finding biologically-homogenous groups of patients, and developing a clinical research network will overcome the limitations in target identification, early triage and clinical trials. Hence, leading European institutions and three SMEs will partner with the EFPIA to: a) develop in vitro models, and animal models that carry confirmed genetic risks, and in these animals to focus on cross-species endophenotypes (e.g. cognitive function, electrophysiology) to facilitate new drug discovery; b) validate the use of sMRI and fMRI-based endophenotypes in genetically-selected healthy volunteers, infants at risk for ASD, and children and adults (including twins) with and without ASD, as early and surrogate markers for efficacy; and to combine this with PET approaches to provide guidance regarding optimal clinical trial design; and c) identify biomarkers that can be used to stratify patients within an umbrella DSM-diagnosis, thus allowing for targeted clinical trials, individualized treatment and back-translation of subgroup-specific biomarkers into preclinical drug discovery. To increase the chance of a breakthrough we will implement new analytical approaches (e.g. support vector machine learning algorithms) and will actively collaborate with patient groups and other international efforts (e.g. the Autism Genetic Resource Exchange (AGRE)).

Call for proposal

IMI-JU-03-2010
See other projects for this call

Coordinator

F. HOFFMANN-LA ROCHE AG
Address
Grenzacherstrasse 124
4070 Basel
Switzerland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Will Spooren (Dr.)
Administrative Contact
Jason Hannon (Dr.)

Participants (26)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 5 492 667
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Dr.)
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 1 597 042
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Enste-Seebauer (Ms.)
STICHTING RADBOUD UNIVERSITEIT
Netherlands
EU contribution
€ 2 262 122
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maarten Van Langen (Mr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 672 362
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
ISLENSK ERFDAGREINING EHF

Participation ended

Iceland
EU contribution
€ 163 473
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bjorgvin Richardsson (Mr)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 1 998 430
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johannes Peter Henri Burbach (Prof.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 1 643 340
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anja Streb (Ms.)
INSTITUT PASTEUR
France
EU contribution
€ 627 246
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Thierry Planchenault (Dr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 311 536
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 901 286
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Nils Brose (Prof)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 236 722
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr.)
NEUROSEARCH AS

Participation ended

Denmark
Address
Pederstrupvej 93
2750 Ballerup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierandrea Muglia (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 474 097
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johan Forsslöf (Dr.)
ELI LILLY AND COMPANY LTD
United Kingdom
Address
Lilly House Basingview
RG21 4FA Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Shepherd (Mr.)
JANSSEN PHARMACEUTICA NV
Belgium
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Koen Meeussen (Dr.)
INSTITUT DE RECHERCHES SERVIER
France
Address
3 Rue De La Republique
92150 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hugues de Saint-Pierre (Mr.)
VIFOR SA
Switzerland
Address
Rte De Moncor
1752 Villars-sur-glâne
Administrative Contact
Roland Koch (Mr.)
BIRKBECK COLLEGE - UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 835 258
Address
Malet Street
WC1E 7HX London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Craig Bryce (Mr)
UNIVERSITA CAMPUS BIO MEDICO DI ROMA
Italy
EU contribution
€ 120 682
Address
Via Alvaro Del Portillo 21
00128 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gianfilippo Capriotti (Dr.)
AUTISM SPEAKS INC. NON PROFIT CORPORATION
United States
Address
State Road Floor 2 1060
08540 Princeton Nj
Activity type
Other
Administrative Contact
Tom Hetzel (Mr.)
PFIZER LIMITED
United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hannah Hurst (Mrs)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 067 084
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Simone MERGUI (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 196 800
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr)
NOLDUS INFORMATION TECHNOLOGY BV
Netherlands
EU contribution
€ 106 590
Address
Nieuwe Kanaal 5
6709 PA Wageningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Weggeman (Mr)
Laeknisfraedileg myndgreining ltd
Iceland
EU contribution
€ 599 760
Address
Egilsgata
101 Reykjavik
Administrative Contact
Birna Jonsdottir (Dr/Mrs)
ARTTIC
France
EU contribution
€ 184 484
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)