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DIabetes REsearCh on patient sTratification

Objective

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.
There is heterogeneity in who develops diabetes, the rate at which their subsequent diabetes progresses, how they respond to diabetes therapy and who develops micro- and macrovascular complications. In the DIRECT consortium we propose to identify biomarkers to identify subtypes with rapid diabetes development and progression and altered response to diabetes treatments, and develop and use these biomarkers in clinical trials.
Two phenotyping work packages will focus on glycaemic deterioration and therapeutic response. For each, the DIRECT consortium brings considerable existing resource, which will be augmented by large-scale prospective cohort collection with intensive physiological and imaging phenotyping. Additional data will be added, such as existing studies on acute response to intravenous beta-cell secretagogues, and functional genomics on human islets, liver, muscle and adipose tissue, to maximise the power and utility of an innovative integrated biology approach. To enable computational multi-level integration across phenotypes and data types, a robust and secure data repository will be developed with strict data governance. As the ultimate aim of DIRECT is patient stratification, biomarkers arising from the discovery work will be used to design one or more prospective clinical trials. These will validate the biomarker(s) of interest, and establish utility in clinical practice and/or trial design and drug development. As a result, this consortium offers considerable potential to achieve major progress towards a personalized medicines approach to the treatment of type 2 diabetes.

Call for proposal

IMI-JU-03-2010
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Coordinator

SANOFI-AVENTIS DEUTSCHLAND GMBH
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Germany

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernd Jablonka (Dr.)
Principal investigator
Hartmut Ruetten (Dr.)

Participants (25)

UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 1 805 896
Address
Nethergate
DD1 4HN Dundee

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
McLeod Alison-Carleton (Mrs.)
UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 215 444
Address
Claverton Down
BA2 7AY Bath

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pete Hompstead (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 186 288
Address
Piazzale Aldo Moro 7
00185 Roma

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Activity type
Research Organisations
Administrative Contact
Michela Matteoli (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 1 753 950
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristina Holdgaard-Sorensen (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 4 800
Address
Geschwister-scholl-platz
72074 Tuebingen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Fritsche (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 1 817 759
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 284 600
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona

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Activity type
Other
Administrative Contact
JUAN M. ABOLAFIA (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 385 603
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tanya Palalic (Ms.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 2 097 994
Address
Brinellvagen 8
100 44 Stockholm

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Åke Eriksson (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 1 416 593
Address
Rue Michel Ange 3
75794 Paris

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Activity type
Research Organisations
Administrative Contact
Sandra Dupire (Mrs.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 543 444
Address
Albinusdreef 2
2333 ZA Leiden

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karin Wibier (-)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 1 093 889
Address
Norregade 10
1165 Kobenhavn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arnold Boon (-)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 1 635 413
Address
Yliopistonranta 1 E
70211 Kuopio

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Reinikainen (Ms.)
LUNDS UNIVERSITET
Sweden
EU contribution
€ 1 570 964
Address
Paradisgatan 5c
22100 Lund

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jacqueline Postma (Dr.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 378 085
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Helen Gallon (Ms.)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 1 734 738
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gaynor Hughes (Ms.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 1 225 700
Address
Rue Du General Dufour 24
1211 Geneve

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emmanouil Dermitzakis (Prof)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 864 143
Address
Wellington Square University Offices
OX1 2JD Oxford

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr)
UNIVERSITAET ULM
Germany
EU contribution
€ 100 000
Address
Helmholtzstrasse 16
89081 Ulm

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
STICHTING VUMC
Netherlands
EU contribution
€ 1 072 269
Address
De Boelelaan 1117
1081 HV Amsterdam

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Activity type
Research Organisations
Administrative Contact
Yvonne Koppelman (Dr.)
NOVO NORDISK A/S
Denmark
Address
Novo Alle 1
2880 Bagsvaerd

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Ridderstrale (Dr.)
ELI LILLY AND COMPANY LTD
United Kingdom
Address
Lilly House Basingview
RG21 4FA Basingstoke

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr.)
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
France
Address
Rue Carnot 50
92284 Courbevoie

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carole POHER (Ms.)
CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France
EU contribution
€ 201 071
Address
Avenue Oscar Lambret 2
59037 Lille

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guillaume Tueux (Mr.)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Goeggel (Dr.)