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Molecular mechanisms regulating cardiovascular remodeling by Adamts1

Molecular mechanisms regulating cardiovascular remodeling by Adamts1

Objective

Professor Redondo’s group has recently identified Adamts1 as one of the major mediators in vascular wall remodeling. They showed that Adamts1+/-, Adamts1-/- and KD-Adamts1 mice present aortic dilation, aneurysms, medial degeneration and hypotension, leading to the hypothesis that Adamts1 deficiency results in a new familial form of thoracic aortic aneurysm (FTAAD) potentially relevant in human aortic disease. They have also found that nitric oxide synthase (NOS) inhibitors reverse aortic dilation and medial degeneration in Marfan mice and Adamts1-deficient mice. The objective of my project is to study the molecular mechanisms mediating these aortic diseases in mice, and to specifically assess the role of nitric oxide (NO) and related signaling pathways, including those of Adamts1 and its substrates, in the medial degeneration and aortic dilation in both mouse models. I plan to identify potential targets common to both aortopathies and analyze them in patients with syndromic and non-syndromic aortic diseases. I think this project has a strong potential to identify therapeutic targets and prognostic or diagnostic markers for human cardiovascular diseases that constitute one of the major causes of mortality worldwide.

Coordinator

CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)

Address

Calle Melchor Fernandez Almagro 3
28029 Madrid

Spain

Activity type

Research Organisations

EU Contribution

€ 170 121,60

Project information

Grant agreement ID: 703561

Status

Grant agreement terminated

  • Start date

    1 June 2016

  • End date

    15 November 2019

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 170 121,60

  • EU contribution

    € 170 121,60

Coordinated by:

CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)

Spain