Cel Lymph nodes are sites where immune responses are robustly initiated. Paradoxically, they are also very common metastatic sites, where tumour progression is well-tolerated. Robust evidence defines a role for fibroblastic reticular cells (FRCs) in preventing T cells from acquiring effector functions within lymph nodes, and deleting T cells that show self-reactivity. FIBROCAN will test the hypothesis that FRCs systematically shut down anti-tumour T cell responses, testing mechanisms of suppression in vitro and in vivo, and charting tumour antigen presentation by FRCs to T cells for the first time. At the frontier of stromal immunology and cancer biology, FIBROCAN was been designed to inform our fundamental understanding of metastatic cancer progression, particularly relevant to the implementation and design of T cell immunotherapies. This project provides the opportunity for a lasting and multi-disciplinary contribution in the high impact fields of stromal and cancer immunology. Dziedzina nauki social scienceseconomics and businessbusiness and managemententrepreneurshipmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineimmunologyimmunotherapy Słowa kluczowe Stromal immunology Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2015 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Koordynator THE UNIVERSITY OF BIRMINGHAM Wkład UE netto € 195 454,80 Adres Edgbaston B15 2TT Birmingham Zjednoczone Królestwo Zobacz na mapie Region West Midlands (England) West Midlands Birmingham Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 195 454,80