Amorphous and Evolutionary DNA Nanotechnology

Projektinformationen

AEDNA

ID Finanzhilfevereinbarung: 694410

DOI 10.3030/694410

Abgeschlossenes Projekt

EK-Unterschriftsdatum 25 Mai 2016

Startdatum 1 Juni 2016

Enddatum 31 Mai 2021

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 2 157 697,50

EU-Beitrag € 2 157 697,50

Koordiniert durch

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Ziel

Amorphous and evolutionary DNA nanotechnology (AEDNA) explores novel conceptual directions and applications for DNA nanotechnology, which are based on intelligent, DNA-programmed soft hybrid materials, and the utilization of evolutionary principles for the optimization of nucleic acid nanocomponents.
Amorphous DNA nanotechnology first aims at the creation of cell-sized, DNA-programmed microgels – DNA cells – with sensor, computation, communication, and actuator functions. Interacting DNA cells will be arranged into chemical cell consortia and artificial tissues using microfluidics, micromanipulation and 3D bioprinting techniques. Spatially distributed chemical circuits will then be utilized to establish collective behaviors such as quorum sensing, pattern formation, and self-differentiation within these consortia and tissues. The approach will be further scaled up to produce multicomponent DNA gel compositions that become active and differentiate upon mixing.
In evolutionary nanotechnology, techniques derived from directed molecular evolution experiments will be applied to optimize the arrangement of functional nucleic acids on DNA and RNA nanoscaffolds. Compartmentalization and microfluidics will be utilized to screen for nucleic acid nanostructures capable of superstructure formation, and also for the development of ligand-sensitive components for molecular programming. An evolutionary approach will then be applied to amorphous DNA cells, resulting in DNA cell populations which contain individuals with different molecular identities.
The proposal will pave the way for the creation of macroscopic materials with DNA-programmed intelligence, resulting in novel applications for DNA nanotechnology and molecular programming in diverse fields such as environmental and biological sensing, biocatalysis, smart adaptive materials, and soft robotics.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acids
• natural sciences › biological sciences › synthetic biology
• natural sciences › biological sciences › genetics › DNA
• engineering and technology › nanotechnology
• natural sciences › biological sciences › molecular biology › molecular evolution

Schlüsselbegriffe

• AEDNA

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-ADG-2015 - ERC Advanced Grant

Aufforderung zur Vorschlagseinreichung

ERC-2015-AdG

Finanzierungsplan

ERC-ADG - Advanced Grant

Gastgebende Einrichtung

TECHNISCHE UNIVERSITAET MUENCHEN

• Netto-EU-Beitrag: € 2 157 697,50
• Adresse: Arcisstrasse 21 ; 80333 Muenchen ; Deutschland
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 157 697,50

Begünstigte (1)

TECHNISCHE UNIVERSITAET MUENCHEN

Deutschland

• Netto-EU-Beitrag: € 2 157 697,50
• Adresse: Arcisstrasse 21 ; 80333 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 2 157 697,50