Bile acid, immune-metabolism, lipid and glucose homeostasis

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Pubblicazioni

Hepatic sexual dimorphism - implications for non-alcoholic fatty liver disease.

Autori: Philippe Lefebvre; Bart Staels
Pubblicato in: "Nature Reviews Endocrinology, Nature Publishing Group, 2021, 17 (11), pp.662-670. ⟨10.1038/s41574-021-00538-6⟩", Numero 33, 2021, ISSN 1759-5037
Editore: Springer Nature
DOI: 10.1038/s41574-021-00538-6

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Autori: Audrey Deprince; Joel T. Haas; Bart Staels
Pubblicato in: ISSN: 2212-8778, Numero 31, 2020, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101092

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Autori: Deckmyn, Benjamin; Domenger, Dorothée; Blondel, Chloé; Ducastel, Sarah; Nicolas, Emilie; Dorchies, Emilie; Caron, Emilie; Charton, Julie; Vallez, Emmanuelle; Deprez, Benoit; Annicotte, Jean-Sébastien; LESTAVEL, Sophie; Tailleux, Anne; Magnan, Christophe; Staels, Bart; Bantubungi, Kadiombo
Pubblicato in: "Frontiers in Molecular Neuroscience, Frontiers Media, 2022, 14, pp.808603. ⟨10.3389/fnmol.2021.808603⟩", Numero 17, 2022, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.808603

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes.

Autori: Chávez-Talavera, Oscar; Wargny, Matthieu; Pichelin, Matthieu; Descat, Amandine; Vallez, Emmanuelle; Kouach, Mostafa; Bigot-Corbel, Edith; Joliveau, Marielle; Goossens, Jean-François; Le May, Cédric; Hadjadj, Samy; Hanf, Rémy; Tailleux, Anne; Staels, Bart; Cariou, Bertrand
Pubblicato in: https://www.hal.inserm.fr/inserm-02869470, Numero 17, 2020, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2019.154042

Metabolic and innate immune cues merge into a specific inflammatory response via unfolded proteinresponse (UPR)

Autori: Mogilenko, D. (Denis); Haas, J. (Joël); L'homme, L. (Laurent); Fleury, S. (Sébastien); Quemener, S. (Sandrine); Levavasseur, M. (Matthieu); Becquart, C. (Coralie); Wartelle, J. (Julien); Bogomolova, A. (Alexandra); Pineau, L. (Laurent); Molendi-Coste, O. (Olivier); Lancel, S. (Steve); Dehondt, H. (Hélène); Gheeraert, C. (Céline); Melchior, A. (Aurélie); Dewas, C. (Cédric); Nikitin, A. (Arte
Pubblicato in: EISSN: 1097-4172, Numero 33, 2019, ISSN 1097-4172
Editore: Elsevier
DOI: 10.1016/j.cell.2019.03.018

Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Autori: Haas, Joel T.; Vonghia, Luisa; Mogilenko, Denis A.; Verrijken, An; Molendi-Coste, Olivier; Fleury, Sébastien; Deprince, Audrey; Nikitin, Artemii; Woitrain, Eloïse; Ducrocq-Geoffroy, Lucie; Pic, Samuel; Derudas, Bruno; Dehondt, Hélène; Gheeraert, Céline; Van Gaal, Luc; Driessen, Ann; Lefebvre, Philippe; Staels, Bart; Francque, Sven; Dombrowicz, David
Pubblicato in: Nature Metabolism, Numero 31, 2019, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-019-0076-1

Hepatic molecular signatures highlight the sexual dimorphism of Non-Alcoholic SteatoHepatitis (NASH)

Autori: Vandel, Jimmy; Dubois-Chevalier, Julie; Gheeraert, Celine; Derudas, Bruno; Raverdy, Violetta; Thuillier, Dorothée; Van Gaal, Luc; Francque, Sven; Pattou, Francois; Staels, Bart; Eeckhoute, Jérôme; Lefebvre, Philippe
Pubblicato in: Hepatology (Baltimore, Md.), Numero 15273350, 2021, ISSN 1527-3350
Editore: John Wiley & Sons
DOI: 10.1002/hep.31312

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Autori: J. Gillard, L.A. Clerbaux, M. Nachit, C. Sempoux, B. Staels, L.B. Bindels, A. Tailleux, I.A. Leclercq
Pubblicato in: JHEP Reports, Numero 4, 2022, Pagina/e 100387, ISSN 2589-5559
Editore: Elsevier
DOI: 10.1016/j.jhepr.2021.10.0387

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.

Autori: Vanessa Hoguet; Manuel Lasalle; Mathieu Maingot; Geoffroy Dequirez; Rajaa Boulahjar; Florence Leroux; Catherine Piveteau; Adrien Herledan; Alexandre Biela; Julie Dumont; Oscar Chávez-Talavera; Loic Belloy; Isabelle Duplan; Nathalie Hennuyer; Laura Butruille; Sophie Lestavel; Emmanuel Sevin; Maxime Culot; Fabien Gosselet; Bart Staels; Benoit Deprez; Anne Tailleux; Julie Charton
Pubblicato in: "Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩", Numero 27, 2021, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01774

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology.

Autori: Vanessa Dubois; Bart Staels; Philippe Lefebvre; Michael P. Verzi; Jérôme Eeckhoute
Pubblicato in: https://hal.archives-ouvertes.fr/hal-02953857, Numero 13, 2020, ISSN 2073-4409
Editore: Basel: MDPI AG
DOI: 10.3390/cells9102185

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

Autori: Margerie, Daniel; Lefebvre, Philippe; Raverdy, Violeta; Schwahn, Uwe; Ruetten, Hartmut; Larsen, Philip; Duhamel, Alain; Labreuche, Julien; Thuillier, Dorothée; Derudas, Bruno; Gheeraert, Céline; Dehondt, Hélène; Dhalluin, Quentin; Alexandre, Jérémy; Caiazzo, Robert; Nesslany, Pamela; Verkindt, Helene; Pattou, François; Staels, Bart
Pubblicato in: "BMC Medical Genomics, BioMed Central, 2019, 12 (1), pp.80. ⟨10.1186/s12920-019-0536-1⟩", Numero 17558794, 2019, ISSN 1755-8794
Editore: BioMed Central
DOI: 10.1186/s12920-019-0536-1

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

Autori: Bobowski-Gerard, Marie; Zummo, Francesco; Staels, Bart; Lefebvre, Philippe; Eeckhoute, Jérôme
Pubblicato in: https://www.hal.inserm.fr/inserm-02154783, Numero 25, 2018, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells7090137

Hypothalamic bile acid-TGR5 signaling protects from obesity.

Autori: Ashley Castellanos-Jankiewicz; Omar Guzmán-Quevedo; Omar Guzmán-Quevedo; Valérie S. Fénelon; Philippe Zizzari; Carmelo Quarta; Luigi Bellocchio; Anne Tailleux; Julie Charton; Daniela Fernandois; Marcus Henricsson; Catherine Piveteau; Vincent Simon; Camille Allard; Sandrine Quemener; Valentine Guinot; Nathalie Hennuyer; Alessia Perino; Alexia Duveau; Marlène Maitre; Thierry Leste-Lasserre; Sam
Pubblicato in: "Cell Metabolism, Elsevier, 2021, Online ahead of print. ⟨10.1016/j.cmet.2021.04.009⟩", Numero 39, 2021, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.04.0099

GIANT : Galaxy-based tool for Interactive ANalysis of Transcriptomic data

Autori: Jimmy Vandel; Céline Gheeraert; Bart Staels; Jérôme Eeckhoute; Philippe Lefebvre; Julie Dubois-Chevalier
Pubblicato in: EISSN: 2045-2322, Numero 34, 2020, Pagina/e Springer Nature, ISSN 2073-4409
Editore: Springer Nature
DOI: 10.1038/s41598-020-76769-w

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

Autori: Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
Pubblicato in: Gut, Numero 67/2, 2018, Pagina/e 271-283, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-313316

The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions

Autori: Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A. Sérandour, Céline Gheeraert, Penderia Guillaume, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S. Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Pubblicato in: Genome Research, Numero 27/6, 2017, Pagina/e 985-996, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.217075.116

Alternative macrophages in atherosclerosis: not always protective!

Autori: Benoit Pourcet, Bart Staels
Pubblicato in: Journal of Clinical Investigation, Numero 128/3, 2018, Pagina/e 910-912, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI120123

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects

Autori: Vanessa Legry, Sven Francque, Joel T Haas, An Verrijken, Sandrine Caron, Oscar Chávez-Talavera, Emmanuelle Vallez, Luisa Vonghia, Eveline Dirinck, Ann Verhaegen, Mostafa Kouach, Sophie Lestavel, Philippe Lefebvre, Luc Van Gaal, Anne Tailleux, Réjane Paumelle, Bart Staels
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero 102/10, 2017, Pagina/e 3783-3794, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/JC.2017-01397

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Autori: Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, Stéphane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T. Haas, Jérome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P. Burris, Bart Staels, Hélène M. Duez
Pubblicato in: Gastroenterology, Numero 154/5, 2018, Pagina/e 1449-1464.e20, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.12.019

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Autori: Maheul Ploton, Claire Mazuy, Céline Gheeraert, Vanessa Dubois, Alexandre Berthier, Julie Dubois-Chevalier, Xavier Maréchal, Kadiombo Bantubungi, Hélène Diemer, Sarah Cianférani, Jean-Marc Strub, Audrey Helleboid-Chapman, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre
Pubblicato in: Journal of Hepatology, Numero 69/5, 2018, Pagina/e 1099-1109, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2018.06.022

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Autori: Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Loïc Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charton
Pubblicato in: Journal of Medicinal Chemistry, Numero 60/10, 2017, Pagina/e 4185-4211, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01873

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Autori: Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Pubblicato in: Gastroenterology, Numero 152/7, 2017, Pagina/e 1679-1694.e3, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.01.055

IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women

Autori: Denis A. Mogilenko; Denis A. Mogilenko; R. Caiazzo; Laurent L'Homme; Laurent Pineau; Violeta Raverdy; Jerome Noulette; Bruno Derudas; François Pattou; Bart Staels; David Dombrowicz
Pubblicato in: EISSN: 0307-0565, Numero 11, 2021, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-021-00826-1

Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid.

Autori: Jan Freark de Boer; Hilde D. de Vries; Hilde D. de Vries; Anna Palmiotti; Rumei Li; Marwah Doestzada; Joanne A Hoogerland; Jingyuan Fu; Anouk M. La Rose; Marit Westerterp; Niels L. Mulder; Milaine V. Hovingh; Martijn Koehorst; Niels J. Kloosterhuis; Justina C. Wolters; Vincent W. Bloks; Joel T. Haas; David Dombrowicz; Bart Staels; Bart van de Sluis; Folkert Kuipers
Pubblicato in: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1045-1069 (2021), Numero 50, 2021, ISSN 2352-345X
Editore: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2020.12.004

Preview Cell Metabolism, deadline February 7th, 2020 Title Microbiome modulation of host's adaptive immunity through bile acid modification

Autori: Kuipers, F. (Folkert); Freark De Boer, J. (Jan); Staels, B. (Bart)
Pubblicato in: "Cell Metabolism, Elsevier, 2020, 31 (3), pp.445-447. ⟨10.1016/j.cmet.2020.02.006⟩", Numero 13, 2020, ISSN 1932-7420
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.02.006

Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Autori: Bougarne, Nadia; Weyers, Basiel; Desmet, Sofie J; Deckers, Julie; Ray, David W; Staels, Bart; De Bosscher, Karolien
Pubblicato in: "Endocrine reviews, Endocrine Society, 2018, 39 (5), pp.760-802. ⟨10.1210/er.2018-00064⟩", Numero 32, 2018, ISSN 1945-7189
Editore: Endocrine Society
DOI: 10.1210/er.2018-00064

what do the human studies tell?

Autori: Oscar Chávez-Talavera; Joel T. Haas; Guillaume Grzych; Anne Tailleux; Bart Staels
Pubblicato in: ISSN: 0957-9672, Numero 12, 2019, ISSN 0957-9672
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000597

The circadian clock and liver function in health and disease

Autori: Atish Mukherji; Shannon M. Bailey; Bart Staels; Thomas F. Baumert
Pubblicato in: "Journal of Hepatology, Elsevier, 2019, 71 (1), pp.200-211. ⟨10.1016/j.jhep.2019.03.020⟩", Numero 46, 2019, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Autori: Guillaume Grzych; Oscar Chávez-Talavera; Amandine Descat; Dorothée Thuillier; An Verrijken; Mostafa Kouach; Vanessa Legry; Hélène Verkindt; Violeta Raverdy; Benjamin Legendre; R. Caiazzo; Luc Van Gaal; Jean-François Goossens; Réjane Paumelle; Sven Francque; François Pattou; Joel T. Haas; Anne Tailleux; Bart Staels
Pubblicato in: JHEP Reports, Numero 38, 2021, ISSN 2589-5559
Editore: Elsevier
DOI: 10.1016/j.jhepr.2020.100222

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