Bile acid, immune-metabolism, lipid and glucose homeostasis

Publikacje

Hepatic sexual dimorphism - implications for non-alcoholic fatty liver disease.

Autorzy: Philippe Lefebvre; Bart Staels
Opublikowane w: "Nature Reviews Endocrinology, Nature Publishing Group, 2021, 17 (11), pp.662-670. ⟨10.1038/s41574-021-00538-6⟩", Numer 33, 2021, ISSN 1759-5037
Wydawca: Springer Nature
DOI: 10.1038/s41574-021-00538-6

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Autorzy: Audrey Deprince; Joel T. Haas; Bart Staels
Opublikowane w: ISSN: 2212-8778, Numer 31, 2020, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101092

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Autorzy: Deckmyn, Benjamin; Domenger, Dorothée; Blondel, Chloé; Ducastel, Sarah; Nicolas, Emilie; Dorchies, Emilie; Caron, Emilie; Charton, Julie; Vallez, Emmanuelle; Deprez, Benoit; Annicotte, Jean-Sébastien; LESTAVEL, Sophie; Tailleux, Anne; Magnan, Christophe; Staels, Bart; Bantubungi, Kadiombo
Opublikowane w: "Frontiers in Molecular Neuroscience, Frontiers Media, 2022, 14, pp.808603. ⟨10.3389/fnmol.2021.808603⟩", Numer 17, 2022, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.808603

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes.

Autorzy: Chávez-Talavera, Oscar; Wargny, Matthieu; Pichelin, Matthieu; Descat, Amandine; Vallez, Emmanuelle; Kouach, Mostafa; Bigot-Corbel, Edith; Joliveau, Marielle; Goossens, Jean-François; Le May, Cédric; Hadjadj, Samy; Hanf, Rémy; Tailleux, Anne; Staels, Bart; Cariou, Bertrand
Opublikowane w: https://www.hal.inserm.fr/inserm-02869470, Numer 17, 2020, ISSN 0026-0495
Wydawca: Elsevier BV
DOI: 10.1016/j.metabol.2019.154042

Metabolic and innate immune cues merge into a specific inflammatory response via unfolded proteinresponse (UPR)

Autorzy: Mogilenko, D. (Denis); Haas, J. (Joël); L'homme, L. (Laurent); Fleury, S. (Sébastien); Quemener, S. (Sandrine); Levavasseur, M. (Matthieu); Becquart, C. (Coralie); Wartelle, J. (Julien); Bogomolova, A. (Alexandra); Pineau, L. (Laurent); Molendi-Coste, O. (Olivier); Lancel, S. (Steve); Dehondt, H. (Hélène); Gheeraert, C. (Céline); Melchior, A. (Aurélie); Dewas, C. (Cédric); Nikitin, A. (Arte
Opublikowane w: EISSN: 1097-4172, Numer 33, 2019, ISSN 1097-4172
Wydawca: Elsevier
DOI: 10.1016/j.cell.2019.03.018

Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Autorzy: Haas, Joel T.; Vonghia, Luisa; Mogilenko, Denis A.; Verrijken, An; Molendi-Coste, Olivier; Fleury, Sébastien; Deprince, Audrey; Nikitin, Artemii; Woitrain, Eloïse; Ducrocq-Geoffroy, Lucie; Pic, Samuel; Derudas, Bruno; Dehondt, Hélène; Gheeraert, Céline; Van Gaal, Luc; Driessen, Ann; Lefebvre, Philippe; Staels, Bart; Francque, Sven; Dombrowicz, David
Opublikowane w: Nature Metabolism, Numer 31, 2019, ISSN 2522-5812
Wydawca: Springer Nature
DOI: 10.1038/s42255-019-0076-1

Hepatic molecular signatures highlight the sexual dimorphism of Non-Alcoholic SteatoHepatitis (NASH)

Autorzy: Vandel, Jimmy; Dubois-Chevalier, Julie; Gheeraert, Celine; Derudas, Bruno; Raverdy, Violetta; Thuillier, Dorothée; Van Gaal, Luc; Francque, Sven; Pattou, Francois; Staels, Bart; Eeckhoute, Jérôme; Lefebvre, Philippe
Opublikowane w: Hepatology (Baltimore, Md.), Numer 15273350, 2021, ISSN 1527-3350
Wydawca: John Wiley & Sons
DOI: 10.1002/hep.31312

Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

Autorzy: J. Gillard, L.A. Clerbaux, M. Nachit, C. Sempoux, B. Staels, L.B. Bindels, A. Tailleux, I.A. Leclercq
Opublikowane w: JHEP Reports, Numer 4, 2022, Strona(/y) 100387, ISSN 2589-5559
Wydawca: Elsevier
DOI: 10.1016/j.jhepr.2021.10.0387

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.

Autorzy: Vanessa Hoguet; Manuel Lasalle; Mathieu Maingot; Geoffroy Dequirez; Rajaa Boulahjar; Florence Leroux; Catherine Piveteau; Adrien Herledan; Alexandre Biela; Julie Dumont; Oscar Chávez-Talavera; Loic Belloy; Isabelle Duplan; Nathalie Hennuyer; Laura Butruille; Sophie Lestavel; Emmanuel Sevin; Maxime Culot; Fabien Gosselet; Bart Staels; Benoit Deprez; Anne Tailleux; Julie Charton
Opublikowane w: "Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩", Numer 27, 2021, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01774

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology.

Autorzy: Vanessa Dubois; Bart Staels; Philippe Lefebvre; Michael P. Verzi; Jérôme Eeckhoute
Opublikowane w: https://hal.archives-ouvertes.fr/hal-02953857, Numer 13, 2020, ISSN 2073-4409
Wydawca: Basel: MDPI AG
DOI: 10.3390/cells9102185

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

Autorzy: Margerie, Daniel; Lefebvre, Philippe; Raverdy, Violeta; Schwahn, Uwe; Ruetten, Hartmut; Larsen, Philip; Duhamel, Alain; Labreuche, Julien; Thuillier, Dorothée; Derudas, Bruno; Gheeraert, Céline; Dehondt, Hélène; Dhalluin, Quentin; Alexandre, Jérémy; Caiazzo, Robert; Nesslany, Pamela; Verkindt, Helene; Pattou, François; Staels, Bart
Opublikowane w: "BMC Medical Genomics, BioMed Central, 2019, 12 (1), pp.80. ⟨10.1186/s12920-019-0536-1⟩", Numer 17558794, 2019, ISSN 1755-8794
Wydawca: BioMed Central
DOI: 10.1186/s12920-019-0536-1

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

Autorzy: Bobowski-Gerard, Marie; Zummo, Francesco; Staels, Bart; Lefebvre, Philippe; Eeckhoute, Jérôme
Opublikowane w: https://www.hal.inserm.fr/inserm-02154783, Numer 25, 2018, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells7090137

Hypothalamic bile acid-TGR5 signaling protects from obesity.

Autorzy: Ashley Castellanos-Jankiewicz; Omar Guzmán-Quevedo; Omar Guzmán-Quevedo; Valérie S. Fénelon; Philippe Zizzari; Carmelo Quarta; Luigi Bellocchio; Anne Tailleux; Julie Charton; Daniela Fernandois; Marcus Henricsson; Catherine Piveteau; Vincent Simon; Camille Allard; Sandrine Quemener; Valentine Guinot; Nathalie Hennuyer; Alessia Perino; Alexia Duveau; Marlène Maitre; Thierry Leste-Lasserre; Sam
Opublikowane w: "Cell Metabolism, Elsevier, 2021, Online ahead of print. ⟨10.1016/j.cmet.2021.04.009⟩", Numer 39, 2021, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2021.04.0099

GIANT : Galaxy-based tool for Interactive ANalysis of Transcriptomic data

Autorzy: Jimmy Vandel; Céline Gheeraert; Bart Staels; Jérôme Eeckhoute; Philippe Lefebvre; Julie Dubois-Chevalier
Opublikowane w: EISSN: 2045-2322, Numer 34, 2020, Strona(/y) Springer Nature, ISSN 2073-4409
Wydawca: Springer Nature
DOI: 10.1038/s41598-020-76769-w

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

Autorzy: Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
Opublikowane w: Gut, Numer 67/2, 2018, Strona(/y) 271-283, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2016-313316

The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions

Autorzy: Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A. Sérandour, Céline Gheeraert, Penderia Guillaume, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S. Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Opublikowane w: Genome Research, Numer 27/6, 2017, Strona(/y) 985-996, ISSN 1088-9051
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.217075.116

Alternative macrophages in atherosclerosis: not always protective!

Autorzy: Benoit Pourcet, Bart Staels
Opublikowane w: Journal of Clinical Investigation, Numer 128/3, 2018, Strona(/y) 910-912, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/JCI120123

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects

Autorzy: Vanessa Legry, Sven Francque, Joel T Haas, An Verrijken, Sandrine Caron, Oscar Chávez-Talavera, Emmanuelle Vallez, Luisa Vonghia, Eveline Dirinck, Ann Verhaegen, Mostafa Kouach, Sophie Lestavel, Philippe Lefebvre, Luc Van Gaal, Anne Tailleux, Réjane Paumelle, Bart Staels
Opublikowane w: The Journal of Clinical Endocrinology & Metabolism, Numer 102/10, 2017, Strona(/y) 3783-3794, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/JC.2017-01397

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Autorzy: Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, Stéphane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T. Haas, Jérome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P. Burris, Bart Staels, Hélène M. Duez
Opublikowane w: Gastroenterology, Numer 154/5, 2018, Strona(/y) 1449-1464.e20, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.12.019

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis

Autorzy: Maheul Ploton, Claire Mazuy, Céline Gheeraert, Vanessa Dubois, Alexandre Berthier, Julie Dubois-Chevalier, Xavier Maréchal, Kadiombo Bantubungi, Hélène Diemer, Sarah Cianférani, Jean-Marc Strub, Audrey Helleboid-Chapman, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre
Opublikowane w: Journal of Hepatology, Numer 69/5, 2018, Strona(/y) 1099-1109, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2018.06.022

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Autorzy: Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Loïc Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charton
Opublikowane w: Journal of Medicinal Chemistry, Numer 60/10, 2017, Strona(/y) 4185-4211, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.6b01873

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Autorzy: Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Opublikowane w: Gastroenterology, Numer 152/7, 2017, Strona(/y) 1679-1694.e3, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2017.01.055

IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women

Autorzy: Denis A. Mogilenko; Denis A. Mogilenko; R. Caiazzo; Laurent L'Homme; Laurent Pineau; Violeta Raverdy; Jerome Noulette; Bruno Derudas; François Pattou; Bart Staels; David Dombrowicz
Opublikowane w: EISSN: 0307-0565, Numer 11, 2021, ISSN 0307-0565
Wydawca: Nature Publishing Group
DOI: 10.1038/s41366-021-00826-1

Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid.

Autorzy: Jan Freark de Boer; Hilde D. de Vries; Hilde D. de Vries; Anna Palmiotti; Rumei Li; Marwah Doestzada; Joanne A Hoogerland; Jingyuan Fu; Anouk M. La Rose; Marit Westerterp; Niels L. Mulder; Milaine V. Hovingh; Martijn Koehorst; Niels J. Kloosterhuis; Justina C. Wolters; Vincent W. Bloks; Joel T. Haas; David Dombrowicz; Bart Staels; Bart van de Sluis; Folkert Kuipers
Opublikowane w: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1045-1069 (2021), Numer 50, 2021, ISSN 2352-345X
Wydawca: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2020.12.004

Preview Cell Metabolism, deadline February 7th, 2020 Title Microbiome modulation of host's adaptive immunity through bile acid modification

Autorzy: Kuipers, F. (Folkert); Freark De Boer, J. (Jan); Staels, B. (Bart)
Opublikowane w: "Cell Metabolism, Elsevier, 2020, 31 (3), pp.445-447. ⟨10.1016/j.cmet.2020.02.006⟩", Numer 13, 2020, ISSN 1932-7420
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2020.02.006

Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Autorzy: Bougarne, Nadia; Weyers, Basiel; Desmet, Sofie J; Deckers, Julie; Ray, David W; Staels, Bart; De Bosscher, Karolien
Opublikowane w: "Endocrine reviews, Endocrine Society, 2018, 39 (5), pp.760-802. ⟨10.1210/er.2018-00064⟩", Numer 32, 2018, ISSN 1945-7189
Wydawca: Endocrine Society
DOI: 10.1210/er.2018-00064

what do the human studies tell?

Autorzy: Oscar Chávez-Talavera; Joel T. Haas; Guillaume Grzych; Anne Tailleux; Bart Staels
Opublikowane w: ISSN: 0957-9672, Numer 12, 2019, ISSN 0957-9672
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mol.0000000000000597

The circadian clock and liver function in health and disease

Autorzy: Atish Mukherji; Shannon M. Bailey; Bart Staels; Thomas F. Baumert
Opublikowane w: "Journal of Hepatology, Elsevier, 2019, 71 (1), pp.200-211. ⟨10.1016/j.jhep.2019.03.020⟩", Numer 46, 2019, ISSN 0168-8278
Wydawca: Elsevier BV
DOI: 10.1016/j.jhep.2019.03.020

Autorzy: Guillaume Grzych; Oscar Chávez-Talavera; Amandine Descat; Dorothée Thuillier; An Verrijken; Mostafa Kouach; Vanessa Legry; Hélène Verkindt; Violeta Raverdy; Benjamin Legendre; R. Caiazzo; Luc Van Gaal; Jean-François Goossens; Réjane Paumelle; Sven Francque; François Pattou; Joel T. Haas; Anne Tailleux; Bart Staels
Opublikowane w: JHEP Reports, Numer 38, 2021, ISSN 2589-5559
Wydawca: Elsevier
DOI: 10.1016/j.jhepr.2020.100222

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