Obiettivo Major Depression (MD) is often chronic and characterized by frequent recurrences of symptoms and burden. The need to better understand how and when relevant transitions in symptoms occur is urgent. A seemingly unsolvable scientific problem is the enormous etiological complexity of mental disorders such as MD, involving continuously ongoing gene-environment interactions that act in highly person-specific ways. This hampers accurate assessment of personalized risk. I will use an out-of-the-box and interdisciplinary approach to tackle this problem. MD is not the only phenomenon that is influenced by many factors, is unpredictable and makes sudden transitions. This is also the case for other so-called complex dynamical systems such as climate or water quality of lakes. For the latter systems generic early warning signals (EWS) have been found that indicate the approach of a transition. I hypothesize that transitions in mood can be anticipated using the same generic EWS as reported for other complex dynamical systems. Finding direct evidence for this hypothesis requires a completely novel approach in the field of psychiatry, which would involve (i) a design that captures data of the complete dynamic process within a single individual in order to detect the timing of EWS and sudden transitions in symptoms, prospectively and intra-individually, and (ii) frequent replications of these individual experiments. With help of recent technology and my acquired expertise I will use precisely this novel approach to search for personalized EWS that anticipate critical transitions in depression. This is the aim of my project.Evidence that transitions in mood behave according to principles of complex dynamical systems would change the field majorly. First, it would lead to a new understanding of mental disorders and the way we study them. Second, it would yield a sophisticated novel way of obtaining personalized and clinically relevant information on risk for transitions. Campo scientifico natural sciencescomputer and information sciencessoftwaremedical and health sciencesclinical medicinepsychiatrymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesearth and related environmental scienceshydrologynatural sciencesmathematicsapplied mathematicsdynamical systems Programma(i) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Argomento(i) ERC-CoG-2015 - ERC Consolidator Grant Invito a presentare proposte ERC-2015-CoG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-COG - Consolidator Grant Istituzione ospitante ACADEMISCH ZIEKENHUIS GRONINGEN Contribution nette de l'UE € 1 994 076,00 Indirizzo HANZEPLEIN 1 9713 GZ Groningen Paesi Bassi Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 994 076,00 Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto ACADEMISCH ZIEKENHUIS GRONINGEN Paesi Bassi Contribution nette de l'UE € 1 994 076,00 Indirizzo HANZEPLEIN 1 9713 GZ Groningen Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 994 076,00