The role of immune cells in Alzheimer's disease

Informacje na temat projektu

IMMUNOALZHEIMER

Identyfikator umowy o grant: 695714

DOI 10.3030/695714

Projekt został zamknięty

Data podpisania przez KE 12 Lipca 2016

Data rozpoczęcia 1 Września 2016

Data zakończenia 31 Sierpnia 2022

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 2 500 000,00

Wkład UE € 2 500 000,00

Koordynowany przez

UNIVERSITA DEGLI STUDI DI VERONA
Italy

Publikacje

Peer reviewed articles (19)

LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.

Autorzy: Silvia Dusi; Stefano Angiari; Enrica Caterina Pietronigro; Nicola Lopez; Gabriele Angelini; Elena Zenaro; Vittorina Della Bianca; Gabriele Tosadori; Gabriele Tosadori; Francesca Paris; Antonella Amoruso; Tommaso Carlucci; Gabriela Constantin; Gabriela Constantin; Barbara Rossi
Opublikowane w: Frontiers in Immunology, Numer 4, 2019, ISSN 1664-3224
Wydawca: International Union of Immunological Societies
DOI: 10.3389/fimmu.2019.02436

Common Peripheral Immunity Mechanisms in Multiple Sclerosis and Alzheimer's Disease

Autorzy: Rossi B, Santos-Lima B, Terrabuio E, Zenaro E, Constantin G
Opublikowane w: Frontiers in Immunology, 2021, ISSN 1664-3224
Wydawca: Frontiers

A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis

Autorzy: Maria Tredicine, Chiara Camponeschi, Davide Pirolli, Matteo Lucchini, Mariagrazia Valentini, Maria Concetta Geloso, Massimiliano Mirabella, Marco Fidaleo, Benedetta Righino, Camilla Moliterni, Ezio Giorda, Mario Rende, Maria Cristina De Rosa, Maria Foti, Gabriela Constantin, Francesco Ria, Gabriele Di Sante
Opublikowane w: iScience, 2022, ISSN 2589-0042
Wydawca: Cell Press
DOI: 10.1016/j.isci.2022.103763

Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Autorzy: Alessio Montresor, Lara Toffali, Laura Fumagalli, Gabriela Constantin, Antonella Rigo, Isacco Ferrarini, Fabrizio Vinante, Carlo Laudanna
Opublikowane w: Journal of Immunology, 2021, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.2001462

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis

Autorzy: Costa S, Bevilacqua D, Caveggion E, Gasperini S, Zenaro E, Donini M, Dusi S, Pettinella F, Constantin G, Lonardi S, Vermi W, De Sanctis F, Ugel S, Cestari T, Abram C, Lowell CA, Rodegher P, Tagliaro F, Girolomoni G, Cassatella MA and Scapini P.
Opublikowane w: Frontiers in Immunology, 2022, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2022.1049079

The role of neutrophils in the dysfunction of central nervous system barriers

Autorzy: Bruno Santos-Lima; Enrica Caterina Pietronigro; Eleonora Terrabuio; Elena Zenaro; Gabriela Constantin
Opublikowane w: Frontiers in Aging Neuroscience, Numer 1, 2022, ISSN 1663-4365
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnagi.2022.965169

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.

Autorzy: Kevin Peikert; Kevin Peikert; Enrica Federti; Alessandro Matte; Gabriela Constantin; Enrica Caterina Pietronigro; Paolo F. Fabene; Paola Defilippi; Emilia Turco; Federico Del Gallo; Pietro Pucci; Angela Amoresano; Anna Illiano; Flora Cozzolino; Maria Chiara Monti; Francesca Garello; Enzo Terreno; Seth L. Alper; Hannes Glaß; Lisann Pelzl; Katja Akgün; Tjalf Ziemssen; Rainer Ordemann; Florian Lang
Opublikowane w: Acta Neuropathologica Communications, 2021, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-021-01181-y

In vitro Models of Neurodegenerative Diseases

Autorzy: Slanzi A, Iannoto G, Rossi B, Zenaro E, Constantin G
Opublikowane w: Frontiers in cell and developmental biology, 2020, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2020.00328

NETosis in Alzheimer’s Disease

Autorzy: Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
Opublikowane w: Frontiers in Immunology, Numer 8, 2017, ISSN 1664-3224
Wydawca: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00211

The blood-brain barrier in Alzheimer's disease

Autorzy: Elena Zenaro, Gennj Piacentino, Gabriela Constantin
Opublikowane w: Neurobiology of Disease, Numer 107, 2017, Strona(/y) 41-56, ISSN 0969-9961
Wydawca: Academic Press
DOI: 10.1016/j.nbd.2016.07.007

Functional morphology of the blood–brain barrier in health and disease

Autorzy: Stefan Liebner, Rick M. Dijkhuizen, Yvonne Reiss, Karl H. Plate, Dritan Agalliu, Gabriela Constantin
Opublikowane w: Acta Neuropathologica, Numer 135/3, 2018, Strona(/y) 311-336, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-018-1815-1

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis

Autorzy: Rossi, Barbara; Constantin, Gabriela
Opublikowane w: Frontiers in Immunology, Vol 7 (2016), Numer 2, 2016, ISSN 1664-3224
Wydawca: Frontiers in Immunology
DOI: 10.3389/fimmu.2016.00506/full

Targeting neuroinflammation in the treatment and prevention of Alzheimer's disease

Autorzy: E. Zenaro, G. Constantin
Opublikowane w: Drugs of the Future, Numer 42/1, 2017, Strona(/y) 21, ISSN 0377-8282
Wydawca: Prous Science
DOI: 10.1358/dof.2017.042.01.2564104

Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis

Autorzy: Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti
Opublikowane w: Scientific Reports, Numer 8/1, 2018, Strona(/y) 1-11, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-25676-2

Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

Autorzy: Xingli Zhang, Yan Wang, Jia Yuan, Ni Li, Siyu Pei, Jing Xu, Xuan Luo, Chaoming Mao, Junli Liu, Tao Yu, Shucheng Gan, Qianqian Zheng, Yinming Liang, Weixiang Guo, Ju Qiu, Gabriela Constantin, Jin Jin, Jun Qin, Yichuan Xiao
Opublikowane w: The Journal of Experimental Medicine, Numer 215/5, 2018, Strona(/y) 1365-1382, ISSN 0022-1007
Wydawca: Rockefeller University Press
DOI: 10.1084/jem.20171417

Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Autorzy: Enrica Pietronigro, Elena Zenaro, Vittorina Della Bianca, Silvia Dusi, Eleonora Terrabuio, Giulia Iannoto, Anna Slanzi, Somayehsadat Ghasemi, Rajasekar Nagarajan, Gennj Piacentino, Gabriele Tosadori, Barbara Rossi, Gabriela Constantin
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-48538-x

The emerging role of neutrophils in neurodegeneration.

Autorzy: Barbara Rossi; Gabriela Constantin; Elena Zenaro
Opublikowane w: Immunobiology, 2019, ISSN 0171-2985
Wydawca: Elsevier BV
DOI: 10.1016/j.imbio.2019.10.014

Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation.

Autorzy: Xu J, Yu T, Pietronigro EC, Yuan J, Arioli J, Pei Y, Luo X, Ye J, Constantin G, Mao C, Xiao Y.
Opublikowane w: Plos Biology, 2020, ISSN 1544-9173
Wydawca: Public Library of Science
DOI: 10.1371/journal.pbio.3000837

Vaccination with (1-11)E2 in alum efficiently induces an antibody response to β-amyloid without affecting brain β-amyloid load and microglia activation in 3xTg mice.

Autorzy: Francesca Mantile; Angelo Capasso; Nàdia Villacampa; Maria Donnini; Giovanna L. Liguori; Gabriela Constantin; Piergiuseppe De Berardinis; Michael T. Heneka; Antonella Prisco
Opublikowane w: Aging Clinical and Experimental Research, 2019, ISSN 1720-8319
Wydawca: Springer
DOI: 10.1007/s40520-019-01414-0