CORDIS
EU research results

CORDIS

English EN
Unraveling Principles of PDZ-mediated Cell Signaling

Unraveling Principles of PDZ-mediated Cell Signaling

Objective

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role in trafficking and organizing diverse cell signaling assemblies, thereby allowing information to be transmitted from receptors, ion channels and transporters in the cell membrane. PDZ domain mediated interactions are emerging as conceptually novel and promising drug targets, with exciting opportunities for the development of novel therapies, especially within cancer and brain diseases. We will establish a European multidisciplinary platform integrating a plethora of complementary life science disciplines that range from chemical development of inhibitors to studies in live animals. The network encompasses 8 academic and 2 industrial beneficiaries as well as one industrial and one academic partner, which are all committed to promote frontline research, innovation and educational activities within the study of PDZ domain-mediated signal transduction pathways related to brain diseases and cancer. This interdisciplinary network will establish an outstanding training opportunity for Early Stage Researchers, who will be integrated in projects unraveling intracellular PDZ domain interactomes to provide pertinent information for discovering drug-related interactions. In a comprehensive and integrated training effort, involving a combination of scientific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KOBENHAVNS UNIVERSITET

Address

Norregade 10
1165 Kobenhavn

Denmark

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 580 163,76

Participants (9)

Sort alphabetically

Sort by EU Contribution

Expand all

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 307 418,41

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 527 318,64

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU Contribution

€ 258 061,32

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 249 216,48

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 249 216,48

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 262 875,60

INSTITUT PASTEUR

France

EU Contribution

€ 262 875,60

SYSTASY BIOSCIENCE GMBH

Germany

EU Contribution

€ 456 204,61

NOVO NORDISK A/S

Denmark

EU Contribution

€ 580 163,76

Project information

Grant agreement ID: 675341

Status

Ongoing project

  • Start date

    1 September 2016

  • End date

    31 August 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 733 514,66

  • EU contribution

    € 3 733 514,66

Coordinated by:

KOBENHAVNS UNIVERSITET

Denmark