Obiettivo The triterpenoids are one of the largest and most structurally complex plant natural products. They are widespread in the Plant Kingdom and have a huge array of structures and numerous associated biological activities. They have important roles in plant defence and signalling. They are also exploited by humans as food supplements, drugs and cosmetics across various sectors. In the past the discovery and production of triterpenoids has relied mainly on isolation from extracts of natural sources and subsequent structural elucidation and chemical modification. These methods suffer from low efficiency and high cost, and are not environmentally sustainable. We herein propose a greener and more sustainable but as yet largely unexplored synthetic biology-based approach that involves genome mining and metabolic engineering to synthesise structural variants of triterpenoids, with a view to discovering novel structures with biological activities for various application prospects in a rapid manner. This project will also shed new light on the biosynthetic pathways of triterpenoids by uncovering new genes and enzymes and will open up opportunities for production of important triterpenoids via further metabolic manipulations in plant or microbial ‘green factories’. Campo scientifico engineering and technologyindustrial biotechnologymetabolic engineeringnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2015 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore JOHN INNES CENTRE Contribution nette de l'UE € 183 454,80 Indirizzo NORWICH RESEARCH PARK COLNEY NR4 7UH Norwich Regno Unito Mostra sulla mappa Regione East of England East Anglia Breckland and South Norfolk Tipo di attività Research Organisations Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 183 454,80
