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TRANSlating the role of Mitochondria in Tumorigenesis

Objective

The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-to-date omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.
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Coordinator

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Address

Via Zamboni 33
40126 Bologna

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 516 122,64

Participants (9)

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UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 250 560

OROBOROS INSTRUMENTS GmbH

Austria

EU Contribution

€ 255 934,08

JUSTUS-LIEBIG-UNIVERSITAET GIESSEN

Germany

EU Contribution

€ 249 216,48

GEMEINNUTZIGE SALZBURGER LANDESKLINIKEN BETRIEBSGESELLSCHAFT

Austria

EU Contribution

€ 255 934,08

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 263 659,32

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 273 287,88

BIOCRATES LIFE SCIENCES AG

Austria

EU Contribution

€ 255 934,08

AvantiCell Science Ltd

United Kingdom

EU Contribution

€ 273 287,88

UNIVERSITE DE BORDEAUX

France

EU Contribution

€ 262 875,60

Partners (4)

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FONDAZIONE UMBERTO VERONESI

INNOVA SRL

CEUB.SOC.CONS.ARL

Dynamo Academy srl Impresa Sociale

Project information

Grant agreement ID: 722605

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 856 812,04

  • EU contribution

    € 2 856 812,04

Coordinated by:

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy