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TRANSlating the role of Mitochondria in Tumorigenesis

Objective

The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-to-date omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Coordinator

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Address
Via Zamboni 33
40126 Bologna
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 516 122,64

Participants (9)

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 306 240
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
OROBOROS INSTRUMENTS GmbH
Austria
EU contribution
€ 255 934,08
Address
Schopfstrasse 18
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
Germany
EU contribution
€ 249 216,48
Address
Ludwigstrasse 23
35390 Giessen
Activity type
Higher or Secondary Education Establishments
GEMEINNUTZIGE SALZBURGER LANDESKLINIKEN BETRIEBSGESELLSCHAFT
Austria
EU contribution
€ 255 934,08
Address
Mullner Hauptstrasse 48
5020 Salzburg
Activity type
Other
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 263 659,32
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 273 287,88
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
BIOCRATES LIFE SCIENCES AG
Austria
EU contribution
€ 255 934,08
Address
Eduard Bodem Gasse 8 1 Stock
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AvantiCell Science Ltd

Participation ended

United Kingdom
EU contribution
€ 212 557,24
Address
Gibbsyard Building
KA6 5HW Ayr
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DE BORDEAUX
France
EU contribution
€ 262 875,60
Address
Place Pey Berland 35
33000 Bordeaux
Activity type
Higher or Secondary Education Establishments

Partners (4)

FONDAZIONE UMBERTO VERONESI
Italy
Address
Piazza Velasca 5
20122 Milano
Activity type
Other
INNOVA SRL
Italy
Address
Via Cicerone, 66
00193 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CEUB.SOC.CONS.ARL
Italy
Address
Via Frangipane 6
47032 Bertinoro
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Dynamo Academy srl Impresa Sociale
Italy
Address
Via Ximenes 662
51028 San Marcello Pistoiese
Activity type
Other