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Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network

Objective

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a redundant pathway is inactivated. Thus, targeting a gene that is synthetic lethal together with a cancer-specific mutation will kill only cancer cells while sparing normal cells. Synthetic lethal approaches have been clinically pioneered by members of our consortium, by combining cancer-promoting mutations (e.g. in BRCA2) with inactivating combinations of DNA repair genes. We will use this approach as the scientific frame for our ETN (SYNTRAIN) consisting of 9 academic and 1 SME beneficiary as well as 3 partners. We aim to identify synthetic lethal interactions and exploit them to innovate future breast and ovarian cancer treatments through compound screening and development. SYNTRAIN consists of World leading researchers with complementary knowledge in genome maintenance and stress response pathways, and a critical mass of expertise for providing an excellent training in screening methodologies, mechanistic investigations, and drug discovery. We will offer a structured training program that exceeds the capacities of each individual member. We will educate a future generation of cancer researchers with a high innovative capacity and skills that enhances their career prospects in both academia and industry. Our aims are to train young researchers: i) in techniques preparing for a career in cancer research, ii) in complementary skills relevant for work in academia and the pharma industry and iii) to become creative and entrepreneurial, capable of bridging the gap between basic and applied research.

Coordinator

KOBENHAVNS UNIVERSITET
Net EU contribution
€ 580 163,76
Address
Norregade 10
1165 Kobenhavn
Denmark

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (9)

IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Italy
Net EU contribution
€ 258 061,32
Address
Via Adamello 16
20139 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Other funding
€ 0,00
PANEPISTIMIO PATRON
Greece
Net EU contribution
€ 242 386,92
Address
University Campus Rio Patras
265 04 Rio Patras

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Region
Αχαΐα Δυτική Ελλάδα Κεντρική Ελλάδα
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 527 318,64
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KRAEFTENS BEKAEMPELSE
Denmark
Net EU contribution
€ 290 081,88
Address
Strandboulevarden 49
2100 Koebenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Research Organisations
Other funding
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 546 575,76
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 265 226,76
Address
Rue Du General Dufour 24
1211 Geneve

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Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
Net EU contribution
€ 510 748,56
Address
Plesmanlaan 121
1066 CX Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Other funding
€ 0,00
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
Net EU contribution
€ 242 386,92
Address
6 Christou Lada Str
10561 Athina

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Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
KANCERA AB
Sweden
Net EU contribution
€ 527 318,64
Address
Banvaktsvagen 22 Karolinska Institutet Science Park
171 48 Solna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Partners (3)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MISVIK BIOLOGY OY
Finland
Net EU contribution
€ 0,00
Address
Karjakatu 35 B
20520 Turku

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Etelä-Suomi Varsinais-Suomi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
Net EU contribution
€ 0,00
Address
Frankfurter Strasse 250
64293 Darmstadt

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 0,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00