Skip to main content

Synaptic dysfunction in Neurodegenerative Diseases

Objective

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, aggregation and spread in NDDs. A key problem in research on NDDs has been that the normal physiological roles at synapses of the aggregation-prone proteins (β- amyloid/amyloid precursor protein, tau, α-synuclein and huntingtin), which are linked pathologically and genetically to these diseases, are not known. Using cutting-edge technologies and multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in interdisciplinary, innovative and collaborative research aimed at the development of novel molecular based treatment strategies for these major diseases of aging. A gap in the training of students in these important diseases is that disease expertise and novel methods to study synapses are localized in isolated groups in different locations in the EU. Similar questions are being asked about the mechanisms of synaptic dysfunction in AD, PD and HD, but no one university or company has sufficiently broad knowledge and technical expertise required to study and develop therapies for synaptic dysfunction in these disorders. This training programme will be implemented in 6 academic centres and 2 SMEs representing a comprehensive, highly interactive and multidisciplinary partnership.

Coordinator

LUNDS UNIVERSITET
Net EU contribution
€ 790 977,96
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (7)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 273 287,88
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East of England East Anglia Cambridgeshire CC
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 788 626,80
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
Net EU contribution
€ 249 216,48
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
Net EU contribution
€ 498 432,96
Address
Venusberg-campus 1/99
53127 Bonn
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Net EU contribution
€ 265 226,76
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
EXPLORA NOVA SARL

Participation ended

France
Net EU contribution
€ 0,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Rue Alfred Kastler 15
17011 La Rochelle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Nouvelle-Aquitaine Poitou-Charentes Charente-Maritime
 
UMECRINE AB
Sweden
Net EU contribution
€ 263 659,32
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Norrlands Universitetssjukhus
901 85 Umea
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Norra Sverige Övre Norrland Västerbottens län
 

Partners (6)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

H. LUNDBECK AS
Denmark
Net EU contribution
€ 0,00
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NEUROPROOF GMBH
Germany
Net EU contribution
€ 0,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Friedrich Barnewitz Str 4
18119 Rostock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Mecklenburg-Vorpommern Mecklenburg-Vorpommern Rostock, Kreisfreie Stadt
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

SKANE LANS LANDSTING
Sweden
Net EU contribution
€ 0,00
Address
.
291 89 Kristianstad
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

SWEDISH PARKINSON FOUNDATION
Sweden
Net EU contribution
€ 0,00
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITAET ULM
Germany
Net EU contribution
€ 0,00
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UMEA UNIVERSITET
Sweden
Net EU contribution
€ 0,00
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Norra Sverige Övre Norrland Västerbottens län