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Synaptic dysfunction in Neurodegenerative Diseases

Objective

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, aggregation and spread in NDDs. A key problem in research on NDDs has been that the normal physiological roles at synapses of the aggregation-prone proteins (β- amyloid/amyloid precursor protein, tau, α-synuclein and huntingtin), which are linked pathologically and genetically to these diseases, are not known. Using cutting-edge technologies and multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in interdisciplinary, innovative and collaborative research aimed at the development of novel molecular based treatment strategies for these major diseases of aging. A gap in the training of students in these important diseases is that disease expertise and novel methods to study synapses are localized in isolated groups in different locations in the EU. Similar questions are being asked about the mechanisms of synaptic dysfunction in AD, PD and HD, but no one university or company has sufficiently broad knowledge and technical expertise required to study and develop therapies for synaptic dysfunction in these disorders. This training programme will be implemented in 6 academic centres and 2 SMEs representing a comprehensive, highly interactive and multidisciplinary partnership.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/basic medicine/neurology/parkinson
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

LUNDS UNIVERSITET
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 790 977,96

Participants (7)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 273 287,88
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 788 626,80
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 249 216,48
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
EU contribution
€ 498 432,96
Address
Sigmund Freud Strasse 27
53127 Bonn
Activity type
Research Organisations
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 265 226,76
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
EXPLORA NOVA SARL

Participation ended

France
EU contribution
€ 0
Address
Rue Alfred Kastler 15
17011 La Rochelle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UMECRINE AB
Sweden
EU contribution
€ 263 659,32
Address
Norrlands Universitetssjukhus
901 85 Umea
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (6)

H. LUNDBECK AS
Denmark
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NEUROPROOF GMBH
Germany
Address
Friedrich Barnewitz Str 4
18119 Rostock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SKANE LANS LANDSTING
Sweden
Address
.
291 89 Kristianstad
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SWEDISH PARKINSON FOUNDATION
Sweden
Address

Stockholm
Activity type
Other
UNIVERSITAET ULM
Germany
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
UMEA UNIVERSITET
Sweden
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments