CORDIS
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CORDIS

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Multidisciplinary European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality

Objective

According to ECDC, over 4 million healthcare-associated infections in the EU cause 37,000 deaths and cost EUR 7 billion/year. Half of them are related to medical devices (i.e., catheters, implants) and 80% of these are related to bacterial biofilms. A recent EC report highlighted the medical device sector’s role in driving EU economic growth, employing 500k people in 25k companies (80% are SMEs) with annual sales of EUR 85 billion. The strategy to prevent medical device-infections is alteration of the device’s surface with antimicrobials. However, current antimicrobial surfaces don’t control bacterial growth in tissue surrounding implants, and only Sterilex® has received regulatory approval in the US as anti-biofilm agent. Participants in this proposal have earlier demonstrated a dramatic in vitro inhibition of biofilm formation by 3D-printing surfaces with antibiotics incorporated into the carrier polymers. This discovery opens new possibilities for printed medical devices that better resist biofilms. Our objective is to set-up a new European education platform to guide and inspire young researchers in the intersectoral exploration of innovative routes to counteract microbial biofilms by fabricating anti-infective, tailored, 3D-printed medical devices. Current opportunities for young researchers to receive an structured, inter-sectoral and up-to-date education on personalized medicine and medical devices are marginal, and to our knowledge PRINT-AID is the first ETN set up for this purpose. State-of-the-art printing technologies will be combined with in vitro and in vivo biofilm models and novel tools for data integration/standardization. Doctoral training will be performed within a high-quality network of 12 participants (5 industrial) from the EU and US. It will include online and face-to-face courses taught by researchers with academic and industrial expertise in biofilms, 3D-printing research, antimicrobials, material science, and drug development.
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Coordinator

HELSINGIN YLIOPISTO

Address

Yliopistonkatu 3
00014 Helsingin Yliopisto

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 538 290,72

Participants (8)

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UNIVERSITEIT GENT

Belgium

EU Contribution

€ 250 560

POLITECHNIKA WARSZAWSKA

Poland

EU Contribution

€ 224 137,44

VOXDALE BVBA

Belgium

EU Contribution

€ 250 560

UNIVERSITEIT ANTWERPEN

Belgium

EU Contribution

€ 250 560

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

APTUIT (VERONA) SRL

Italy

EU Contribution

€ 258 061,32

UNIVERSIDADE DO PORTO

Portugal

EU Contribution

€ 238 356,36

AMC MEDICAL RESEARCH BV

Netherlands

EU Contribution

€ 255 374,28

Partners (4)

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Montana State University Bozeman

United States

MADAM THERAPEUTICS BV

Netherlands

3DTECH OY

Finland

BioSurface Technologies Corporation

United States

Project information

Grant agreement ID: 722467

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 265 900,12

  • EU contribution

    € 2 265 900,12

Coordinated by:

HELSINGIN YLIOPISTO

Finland