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European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry

Objective

The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors and to improve efficiency and on- and off-target toxicity are current challenges Therefore the EN-ACTI2NG program aims 1) to train PhD students with expertise in development of new and improved T cell-mediated cancer immuno-therapies; 2) to endow the PhD students with the ability to establish efficient communication between the academic and industrial research environments and between scientists and the general public; 3) to improve T cell mediated anti-cancer immuno-therapy by the identification and development of new cancer-specific immune receptors and enhancing their function by identifying and modifying their molecular mechanism of action. To reach these objectives we have designed individual research projects ranging from biophysical analysis of immune receptors, via molecular modification of their structure and testing their tumor killing capacity in cell-based and pre-clinical assays to product development. Secondments will assure that each PhD student will be exposed to these complementary approaches and that there will be synergic feedback between the projects, producing innovative results that could otherwise not be achieved. Extensive training in research-specific skills, career development and a continuous training in communication skills will allow the PhD students to become facilitators of the process of transformation of scientific innovation into products with social and economic value. As such, the EN-ACTI2NG program should contribute to overcoming the more general challenge of converting the European Community into an innovation-driven society.

Field of science

  • /natural sciences/mathematics/pure mathematics/geometry
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
28006 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 247 872,96

Participants (10)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 249 216,48
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET ZU KOELN

Participation ended

Germany
EU contribution
€ 62 304,12
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 255 374,28
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 255 934,08
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 255 934,08
Address
Karlsplatz 13
1040 Wien
Activity type
Higher or Secondary Education Establishments
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Spain
EU contribution
€ 247 872,96
Address
Avenida De Pio Xii 55
31008 Pamplona
Activity type
Research Organisations
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 273 287,88
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU contribution
€ 249 216,48
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
STRATEC CONSUMABLES GMBH
Austria
EU contribution
€ 255 934,08
Address
Sonystrasse 20
5081 Anif
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 159 221,64
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Activity type
Higher or Secondary Education Establishments

Partners (2)

CELLULAR THERAPEUTICS LIMITED
United Kingdom
Address
Hawthorn Lane 34 Heald Court 3
SK9 5DG Wilmslow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SCIENSEED SL
Spain
Address
Calle Arte 3 5/A
28033 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)