European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry

Project Information

EN_ACTI2NG

Grant agreement ID: 721358

DOI 10.3030/721358

Project closed

EC signature date 31 August 2016

Start date 1 January 2017

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 2 539 859,76

EU contribution € 2 539 859,76

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Deliverables

Documents, reports (9)

2nd annual meeting

2nd annual meeting report

workshop GMP and SOP design

Handbook GMP and SOP design, elaborated in conjunction with partner Cellular Therapeutics

International Immunology Meeting Freiburg 2018

Program 2018 International Immunology Meeting Freiburg

workshop from bench to bedside

handbook workshop 'Form bench to bedside'

3rd annual meeting

3rd annual meeting report

1st annual meeting

1st annual meeting report

workshop aptamer selection and therapeutic application

handbook HT-SELEX-mediated aptamer selection and therapeutic application

workshop T cell-based gene therapy

Handbook T cell-based gene therapy

workshop super-resolution fluorescence microscopy

handbook super-resolution fluorescence microscopy

Websites, patent fillings, videos etc. (3)

logo and website

website functional

vacancies advertisement

announcement of vacancies via consortium website/EURAXESS/etc and implementation of the application system for candidates

Integration workshop

meeting with all the recruited ESRs and all partners. This meeting will allow the students and partners to get to know each other and will include brief project presentations by all partners, explanation of the network structure and function, and rights and obligations of all participants.

Publications

Peer reviewed articles (11)

ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity

Author(s): Mario Martínez Soldevilla, Helena Villanueva, Daniel Meraviglia-Crivelli, Ashwathi Puravankara Menon, Marta Ruiz, Javier Cebollero, María Villalba, Beatriz Moreno, Teresa Lozano, Diana Llopiz, Álvaro Pejenaute, Pablo Sarobe, Fernando Pastor
Published in: Molecular Therapy, Issue 27/11, 2019, Page(s) 1878-1891, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.013

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

Author(s): Benjamin Salzer, Christina M. Schueller, Charlotte U. Zajc, Timo Peters, Michael A. Schoeber, Boris Kovacic, Michelle C. Buri, Elisabeth Lobner, Omer Dushek, Johannes B. Huppa, Christian Obinger, Eva M. Putz, Wolfgang Holter, Michael W. Traxlmayr
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17970-3

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Author(s): Frederike A. Hartl, Esmeralda Beck-Garcìa, Nadine M. Woessner, Lea J. Flachsmann, Rubí M.-H. Velasco Cárdenas, Simon M. Brandl, Sanaz Taromi, Gina J. Fiala, Anna Morath, Pankaj Mishra, O. Sascha Yousefi, Julia Zimmermann, Nico Hoefflin, Maja Köhn, Birgitta M. Wöhrl, Robert Zeiser, Kristian Schweimer, Stefan Günther, Wolfgang W. Schamel, Susana Minguet
Published in: Nature Immunology, Issue 21/8, 2020, Page(s) 902-913, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0732-3

Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge?

Author(s): Mayte Sola, Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Mario Martínez Soldevilla, Fernando Cartón-García, Fernando Pastor
Published in: Molecular Therapy Nucleic Acids, 2020, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.05.025

Inefficient CAR-proximal signaling blunts antigen sensitivity

Author(s): Venugopal Gudipati, Julian Rydzek, Iago Doel-Perez, Vasco Dos Reis Gonçalves, Lydia Scharf, Sebastian Königsberger, Elisabeth Lobner, Renate Kunert, Hermann Einsele, Hannes Stockinger, Michael Hudecek, Johannes B Huppa
Published in: Nature Immunology, 2020, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0719-0

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working

Author(s): Wolfgang W. Schamel, Balbino Alarcon, Susana Minguet
Published in: Immunological Reviews, Issue 291/1, 2019, Page(s) 8-25, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12788

Chimeric antigen receptors designed to overcome transforming growth factor‐β‐mediated repression in the adoptive T‐cell therapy of solid tumors

Author(s): Jordan Hartley, Hinrich Abken
Published in: Clinical and Translational Immunology, 2019, ISSN 2050-0068
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/cti2.1064

Defocused imaging exploits supercritical-angle fluorescence emission for precise axial single molecule localization microscopy

Author(s): Philipp Zelger, Lisa Bodner, Lukas Velas, Gerhard J. Schütz, Alexander Jesacher
Published in: Biomedical Optics Express, Issue 11/2, 2020, Page(s) 775, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.375678

Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein

Author(s): Lydia Horndler, Pilar Delgado, David Abia, Ivaylo Balabanov, Pedro Martínez‐Fleta, Georgina Cornish, Miguel A Llamas, Sergio Serrano‐Villar, Francisco Sánchez‐Madrid, Manuel Fresno, Hisse M van Santen, Balbino Alarcón
Published in: EMBO Molecular Medicine, Issue 13/3, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013549

Three-dimensional localization microscopy using deep learning

Author(s): P. Zelger, K. Kaser, B. Rossboth, L. Velas, G. J. Schütz, A. Jesacher
Published in: Optics Express, Issue 26/25, 2018, Page(s) 33166, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.26.033166

Three-dimensional single molecule localization close to the coverslip: a comparison of methods exploiting supercritical angle fluorescence

Author(s): Philipp Zelger, Lisa Bodner, Martin Offterdinger, Lukas Velas, Gerhard J. Schütz, and Alexander Jesacher
Published in: Biomedical Optics Express, 2021, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.413018