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Molecule-to-man pain network

Objective

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /natural sciences/biological sciences/biophysics
  • /engineering and technology/environmental biotechnology/bioremediation/bioreactor
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA
Address
Via Giovanni Celoria 11
20133 Milano
Italy
Activity type
Research Organisations
EU contribution
€ 258 061,32

Participants (10)

UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 510 748,56
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 258 061,32
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 258 061,32
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
YALE UNIVERSITY
United States
EU contribution
€ 249 888,24
Address
Whitney Avenue 155 Room 214
06520 8337 New Haven
Activity type
Higher or Secondary Education Establishments
NEUROSCIENCE TECHNOLOGIES SLP

Participation ended

Spain
EU contribution
€ 378 006,27
Address
Baldiri Reixac 15-21
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NSGENE AS

Participation ended

Denmark
EU contribution
€ 0
Address
Baltorpvej 154
2750 Ballerup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DI.V.A.L. TOSCANA SRL
Italy
EU contribution
€ 258 061,32
Address
Via Madonna Del Piano 6
50019 Sesto Fiorentino Fi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 788 626,80
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 258 061,32
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 117 739,65
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments

Partners (2)

CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
Address
Via Giuseppe Mussi 1
20154 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAREERS RESEARCH AND ADVISORY CENTRE (CRAC) LIMITED (THE)
United Kingdom
Address
22 Signet Court Swann Road
CB5 8LA Cambridge
Activity type
Other