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Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease

Objective

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.

Coordinator

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Net EU contribution
€ 476 712,72
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Portugal

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (9)

FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)
Czechia
Net EU contribution
€ 232 422,48
Address
Videnska 1083
142 20 Praha 4

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Region
Praha Hlavní město Praha
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
Net EU contribution
€ 516 122,64
Address
Piazza Umberto I 1
70121 Bari

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Region
Sud Puglia Bari
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Faculdade de Farmácia da Universidade de Lisboa
Portugal
Net EU contribution
€ 238 356,36
Address
Av. Prof. Gama Pinto
1649-003 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 224 137,44
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa

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Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSIDADE DO PORTO
Portugal
Net EU contribution
€ 238 356,36
Address
Praca Gomes Teixeira
4099-002 Porto

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 262 875,60
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Net EU contribution
€ 516 122,64
Address
Piazzale Aldo Moro 7
00185 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 247 872,96
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ASSOCIACAO PROTECTORA DOS DIABETICOS DE PORTUGAL
Portugal
Net EU contribution
€ 0,00
Address
Rua Salitre 118-120
1250-203 Lisboa

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Cetics GmbH
Germany
Net EU contribution
€ 0,00
Address
Schelztorstr. 54-56
73728 Esslingen Am Neckar

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Region
Baden-Württemberg Stuttgart Esslingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH
Germany
Net EU contribution
€ 0,00
Address
Aspenhaustrasse 25
72770 Reutlingen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Baden-Württemberg Tübingen Reutlingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

SEAHORSE BIOSCIENCE EUROPE APS
Denmark
Net EU contribution
€ 0,00
Address
Fruebjergvej 3
2100 Kobenhavn

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Byen København
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00