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Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease

Objective

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /social sciences/economics and business/business and management/employment

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Portugal
Activity type
Research Organisations
EU contribution
€ 476 712,72

Participants (9)

FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)
Czechia
EU contribution
€ 232 422,48
Address
Videnska 1083
142 20 Praha 4
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 516 122,64
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
Faculdade de Farmácia da Universidade de Lisboa
Portugal
EU contribution
€ 238 356,36
Address
Av. Prof. Gama Pinto
1649-003 Lisboa
Activity type
Higher or Secondary Education Establishments
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 224 137,44
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Activity type
Research Organisations
UNIVERSIDADE DO PORTO
Portugal
EU contribution
€ 238 356,36
Address
Praca Gomes Teixeira
4099 002 Porto
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 262 875,60
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 516 122,64
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 249 216,48
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 247 872,96
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations

Partners (4)

Associação Protectora dos Diabéticos de Portugal
Portugal
Address
Rua Do Salitre N.º 118-120
1250-203 Lisboa Lisboa
Activity type
Research Organisations
Cetics GmbH
Germany
Address
Schelztorstr. 54-56
73728 Esslingen Am Neckar
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH
Germany
Address
Aspenhaustrasse 25
72770 Reutlingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SEAHORSE BIOSCIENCE EUROPE APS
Denmark
Address
Fruebjergvej 3
2100 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)