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Tribbles Research and Innovation Network

Objective

This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects described in the proposal will investigate regulators of these pathways with a focus on a recently described family of pseudokinases, namely tribbles proteins, which have a key role in controlling immunity, metabolism and cancer, and which here will serve as prototypical examples for integrative metabolocentric cancer research. Tribbles are envisaged to contribute directly to the development and progression of prostate cancer, the prognosis of which is substantially worsened in individuals with immuno-metabolic disease.
We therefore propose a multidisciplinary research-training programme with an overall objective to uncover cell-specific aspects of tribbles-mediated control of immuno-metabolism and their impact on prostate cancer progression. We will approach this by integrating cell biology and sophisticated in vivo models of both immuno-metabolic disease and prostate cancer, complemented by specialist human disease biobanks, cutting-edge genomics approaches, plus a drug discovery pipeline. This will be carried out by an alliance of leading academic research groups and specialist SMEs with complementary backgrounds in inflammation, adipose tissue biology, tumourigenesis, genomics, translational models of human disease, medicinal chemistry and drug discovery.
This will provide a unique opportunity for a cohort of PhD students to undertake Research Training at the interface of several disciplines and sectors, thereby gaining a diverse portfolio of R&D expertise and transferrable skills as well as exposure to several non-academic career pathways.

Coordinator

THE UNIVERSITY OF SHEFFIELD
Net EU contribution
€ 695 664,17
Address
Firth Court Western Bank
S10 2TN Sheffield
United Kingdom

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO CLINICO SAN CARLOS
Spain
Net EU contribution
€ 495 745,92
Address
Calle Profesor Martin Lagos
28040 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 498 432,96
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITE DE NANTES
France
Net EU contribution
€ 262 875,60
Address
Quai De Tourville 1
44035 Nantes Cedex 1

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Region
Pays de la Loire Pays de la Loire Loire-Atlantique
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 546 575,76
Address
327 Mile End Road
E1 4NS London

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain
Net EU contribution
€ 297 447,55
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya

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Region
Noreste País Vasco Bizkaia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 510 748,56
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSIDADE DA BEIRA INTERIOR
Portugal
Net EU contribution
€ 238 356,36
Address
Convento De Santo Antonio
6201 001 Covilha

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Region
Continente Centro (PT) Beiras e Serra da Estrela
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SEQOMICS BIOTECHNOLOGIA KORLATOLT FELELOSSEGU TARSASAG

Participation ended

Hungary
Net EU contribution
€ 74 824,43
Address
Zoldfasi Ut 29
6791 Szeged

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INTELLIGENT PHARMA SL

Participation ended

Spain
Net EU contribution
€ 130 821,84
Address
C/diputacio 279, 3 - 6
08007 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAT DE BARCELONA
Spain
Net EU contribution
€ 67 476,53
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (7)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

DIVERCHIM SA
France
Net EU contribution
€ 0,00
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MRC Technology
United Kingdom
Net EU contribution
€ 0,00
Address

London

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Basque Biobank for Research
Spain
Net EU contribution
€ 0,00
Address

Bilbao

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Hospital du 12 Octobre
Spain
Net EU contribution
€ 0,00
Address

Madrid

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

PRESIDENT AND FELLOWS OF HARVARD COLLEGE
United States
Net EU contribution
€ 0,00
Address
Massachusetts Avenue 1350
02138 Cambridge

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Labstract Ltd
United Kingdom
Net EU contribution
€ 0,00
Address

Cambridge

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITATSKLINIKUM HEIDELBERG
Germany
Net EU contribution
€ 0,00
Address
Im Neuenheimer Feld 672
69120 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00