CORDIS
EU research results

CORDIS

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An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment

Project information

Grant agreement ID: 721975

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 860 843,40

  • EU contribution

    € 3 860 843,40

Coordinated by:

STICHTING VU

Netherlands

Objective

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.

Coordinator

STICHTING VU

Address

De Boelelaan 1105
1081 Hv Amsterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 510 748,56

Participants (13)

EVERCYTE GMBH

Austria

EU Contribution

€ 255 934,08

UNIVERSITE D'ARTOIS

France

EU Contribution

€ 262 875,60

UNIVERSITE DE LAUSANNE

Switzerland

EU Contribution

€ 265 226,76

BIOTALENTUM TUDASFEJLESZTO KFT

Hungary

EU Contribution

€ 223 913,52

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 250 560

Department of Health

United Kingdom

EU Contribution

€ 273 287,88

NEWCELLS BIOTECH LIMITED

United Kingdom

EU Contribution

€ 273 287,88

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU Contribution

€ 516 122,64

LIVERPOOL JOHN MOORES UNIVERSITY

United Kingdom

EU Contribution

€ 273 287,88

KEMIJSKI INSTITUT

Slovenia

EU Contribution

€ 234 997,56

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 255 374,28

EDELWEISS CONNECT GMBH

Switzerland

EU Contribution

€ 265 226,76

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

Partners (5)

UNIVERSITAT KONSTANZ

Germany

European Union Reference Laboratory for Alternative Methods to Animal Testing

Italy

European Society of Toxicology in Vitro

Netherlands

NANOTECH PARTNER SRO

Czechia

L'OREAL SA

France

Project information

Grant agreement ID: 721975

Status

Ongoing project

  • Start date

    1 January 2017

  • End date

    31 December 2020

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 860 843,40

  • EU contribution

    € 3 860 843,40

Coordinated by:

STICHTING VU

Netherlands