Insights into the role of phages on the bacterial resistome

Projektinformationen

ROPHARE

ID Finanzhilfevereinbarung: 659314

DOI 10.3030/659314

Abgeschlossenes Projekt

EK-Unterschriftsdatum 26 November 2015

Startdatum 26 Dezember 2016

Enddatum 25 Dezember 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 254 480,40

EU-Beitrag € 254 480,40

Koordiniert durch

FUNDACION RIOJA SALUD-FRS
Spain

Ziel

There is an imperative need to gain knowledge on the spread and evolution of antimicrobial resistance (AMR). Recent evidence from environmental, animal and human microbial studies shows that AMR is ancient and environments without contact with anthropogenic antibiotics possess abundant AMR genes. Bacteriophages are the most abundant entities in Earth and recent studies provide indirect evidence for the major role of transduction in the dissemination of AMR genes. Hence, phages might be of critical importance for evading one of the bottlenecks (ecological connectivity) that modulates the transmission of AMR genes from natural environments to animal and human biomes.
In this proposal, a holistic and multidisciplinary approach that combines molecular genetics, genomics, metagenomics, in-vitro experimental analysis, computational biology, bioinformatics analysis, and modelling will be followed to measure the potential of naturally occurring phages to be vehicles for AMR transmission and spread in environmental systems with different antibiotic selective pressure. This comprehensive approach will allow us to better understand the phage-bacteria interactions that drive the AMR spread in different ecosystems. From this understanding we expect to be able to design and develop new tools for the control of antimicrobial resistance in clinical and veterinary practice as well as in agriculture.
This project will contribute to the objectives of the Work Programme by: 1) allowing the researcher to gain new skills and additional training-through-research in phage and phage-bacteria interactions, computational and (meta)genomic analysis; and to become an EU leading specialist in a research field with emerging growth potential; 2) transferring the acquired knowledge to the EU; 3) establish a long-term collaboration between several centres of excellence that will enhance the quality of research of Europe and make it more competitive and attractive for high-profile researchers.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › microbiology › virology
• natural sciences › biological sciences › genetics › genomes › viral genomes
• natural sciences › earth and related environmental sciences › soil sciences › edaphology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › antibiotics

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2014

Finanzierungsplan

MSCA-IF-GF - Global Fellowships

Koordinator

FUNDACION RIOJA SALUD-FRS

• Netto-EU-Beitrag: € 254 480,40
• Adresse: CALLE PIQUERAS 98 ; 26006 Logrono ; Spanien
• Region: Noreste › La Rioja › La Rioja
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 254 480,40

Partner (1)

Partner

Partnerorganisationen tragen zur Umsetzung der Aktion bei, unterzeichnen jedoch nicht die Finanzhilfevereinbarung.

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Schweiz

• Netto-EU-Beitrag: € 0,00
• Adresse: Raemistrasse 101 ; 8092 Zuerich
• Region: Schweiz/Suisse/Svizzera › Zürich › Zürich
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 175 419,60