Cel This proposal will focus on the hippocampal mossy fiber (MF) synapse, formed between the axons of dentate gyrus granule cells and CA3 pyramidal neurons. The hippocampus plays an important role in learning and memory formation and MF synapses are involved in processing, storage and recall of spatial information. The MF tract connects the entorhinal cortex to CA3 pyramidal neurons. MF presynaptic terminals are large in size, forming giant synapses on proximal dendrites of CA3 pyramidal neurons. Based on this structure, the MF synapse is proposed to have a key role in hippocampal function as a “detonator synapse” that reliably discharges the postsynaptic target neurons. Additionally, it is thought to be involved in storage of information in the CA3 region network by triggering synaptic plasticity between these pyramidal neurons. Despite its important role in hippocampal function and plasticity, there is still very limited information about this key synapse. This proposal will investigate the nanoscale location and distribution of presynaptic voltage-gated calcium channels (VGCCs) at the hippocampal mossy fiber synapse and how it influences coupling at this presynaptic terminal. The opening of VGCCs at presynaptic terminals leads to calcium entry and a subsequent rise in concentration in the vicinity of the channels. The spatial volume occupied by this increased calcium concentration is referred to as calcium domains. The coupling distance between these domains and calcium sensors at the release machinery of docked synaptic vesicles is critical as it determines speed and precision of fusion of vesicles and, thus, release of neurotransmitters. Results from these observations would form the basis for a quantitative understanding of mechanisms underlying time-course of transmission and presynaptic plasticity at this synapse and thus, how it relates to their particular network function in hippocampus. Dziedzina nauki natural sciencesbiological sciencesneurobiologyengineering and technologymaterials engineeringfibersmedical and health sciencesbasic medicineneurologyepilepsynatural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencescomputer and information sciencesartificial intelligencecomputational intelligence Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2015 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-EF-ST - Standard EF Koordynator INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Wkład UE netto € 166 156,80 Adres Am Campus 1 3400 Klosterneuburg Austria Zobacz na mapie Region Ostösterreich Niederösterreich Wiener Umland/Nordteil Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 166 156,80