SABANA aims at developing a large-scale integrated microalgae-based biorefinery for the production of biostimulants, biopesticides and feed additives, in addition to biofertilizers and aquafeed, using only marine water and nutrients from wastewaters (sewage, centrate and pig manure). The objective is to achieve a zero waste process at a demonstration scales up to 5 ha sustainable both environmentally and economically. A Demonstration Centre of this biorefinery will be operated to demonstrate the technology, assess the operating characteristics of the system, evaluate environment impacts and collaborate with potential customers for use. The key advantages of SABANA project are: the sustainability of the process, using marine water and recovering nutrients from wastewaters while minimizing the energy consumption, and the socioeconomic benefits, due to the relevance of the target bioproducts for two major pillars in food production as agriculture and aquaculture. Bioproducts capable of increasing the yield of crops and fish production are highly demanded, whereas recovery of nutrients is a priority issue in the EU. Instead of considering wastewater as an inevitably useless and problematic residue of our society, SABANA acknowledges its potential as an opportunity for economically relevant sectors. SABANA project includes (i) the utilization of microalgae-bacteria consortia and in co-culture with other algae to control grazing species, (ii) the implementation of efficient thin-layer cascade and raceway, (iii) the scale-up of reactors to ensure stable operation, (iv) to use marine water to increase the sustainability of the process; (v) to recover nutrients from wastewaters, (vi) to develop harvesting processes taking into account the remaining water, (vii) to establish processes for mild/energy efficient extraction of bioproducts, (viii) to process residual biomass to produce biofertilizers and aquafeed in zero-waste schemes, (ix) using robust and sustainable technology.