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Photoacoustic/Ultrasound Mammoscopy for evaluating screening-detected abnormalities in the breast

Objective

X-ray mammography is the mainstay of breast cancer screening programs. It is estimated that between 20 - 50% of abnormal screening mammograms will prove to be negative. The paradigm in diagnosis is to establish whether a lesion is benign or malignant. All the imaging techniques conventionally used today – diagnostic x-ray, ultrasonography and magnetic resonance imaging have many limitations, leading to multiple and/or repeat imaging and often unnecessary biopsy. This leads to physical, psychological and economic burdens felt at individual, familial and societal levels.

With an aging population, high incidence of breast cancer and tightening health-care budgets, there is an urgent requirement for a non-invasive method for in-depth assessment of the screening-detected lesion. In PAMMOTH we will showcase such an imager, combining photoacoustic and ultrasound imaging. With the use of quantitative image reconstruction of multi-wavelength photoacoustic data, information is gained of the vascular and oxygen status of the lesion relating to tumor physiology and function. From the ultrasound part, we derive ultrasound reflection from the lesion in a manner superior to conventional breast ultrasonography, relating to anatomic features and extent of a tumor. This information will enable the radiologist to come to a diagnosis accurately and rapidly without the use of contrast agents, without pain and discomfort to the patient, while being cost-effective and not requiring complex infrastructure.

Four excellent academic groups, three dynamic SMEs, and a hospital come together with support from key stakeholders in an Advisory group, to push beyond the state-of-the-art in science and technology to achieve the PAMMOTH imager. For the SMEs, in addition to tremendous improvements in individual product lines, the new integrated diagnostic imaging instrument opens up completely new market opportunities.

We expect PAMMOTH to have a strong economic and clinical impact.

Call for proposal

H2020-ICT-2016-2017

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Sub call

H2020-ICT-2016-1

Coordinator

UNIVERSITEIT TWENTE
Net EU contribution
€ 864 375,00
Address
Drienerlolaan 5
7522 NB Enschede
Netherlands

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Region
Oost-Nederland Overijssel Twente
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (8)

PA IMAGING R&D BV
Netherlands
Net EU contribution
€ 816 000,00
Address
Drienerlolaan 5
7522 NB Enschede

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Overijssel Twente
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
STICHTING MEDISCH SPECTRUM TWENTE
Netherlands
Net EU contribution
€ 185 000,00
Address
Haaksbergerstraat 55
7513 ER Enschede

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Region
Oost-Nederland Overijssel Twente
Activity type
Other
Other funding
€ 0,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 708 663,75
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITAET BERN
Switzerland
Net EU contribution
€ 0,00
Address
Hochschulstrasse 6
3012 Bern

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Other funding
€ 753 097,50
VYSOKE UCENI TECHNICKE V BRNE
Czechia
Net EU contribution
€ 385 000,00
Address
Antoninska 548/1
601 90 Brno Stred

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
IMASONIC SAS
France
Net EU contribution
€ 760 000,00
Address
Za Rue Des Savourots
70190 Voray Sur L'ognon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bourgogne-Franche-Comté Franche-Comté Haute-Saône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
EKSPLA UAB
Lithuania
Net EU contribution
€ 410 468,75
Address
Savanoriu Pr 231
02300 Vilnius

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Lietuva Sostinės regionas Vilniaus apskritis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
TP21 GMBH
Germany
Net EU contribution
€ 222 500,00
Address
Luisenstrasse 14
10117 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00